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Background <p>One-anastomosis gastric bypass (OAGB) has gained global prominence as the third most performed bariatric procedure. Despite evidence of short-term efficacy, long-term outcomes remain understudied.</p> Methods <p>This PRISMA-compliant systematic review and meta-analysis evaluated long-term (≥ 5&#xa0;years) outcomes of OAGB as primary and revisional procedures. Quality assessment and bias evaluation were conducted systematically.</p> Results <p>Analysis included 32 studies with 19,125 patients (76% primary OAGB) from 14 countries with mean follow-up of 6.7&#xa0;years. At five years, mean excess weight loss(EWL) was 75%, increasing to 77% beyond five years. Obesity associated diseases resolution was substantial: type 2 diabetes (80%), obstructive sleep apnea (89%), and hypertension (61%). Complications were minimal: bile reflux (4%), marginal ulceration (2%), and malnutrition (1%). For revisional OAGB, %EWL at five years was 71%. The conversion rate to other bariatric procedures (all RYGB) was reported in 3% of patients following OAGB.</p> Conclusion <p>This analysis demonstrates OAGB's effectiveness for sustained weight loss and obesity associated diseases improvement at ≥ 5&#xa0;years, supporting its role in long-term obesity management as a primary and revisional bariatric intervention.</p>

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Long-Term Outcomes of One Anastomosis Gastric Bypass: A Systematic Review and Meta-Analysis of 5-Year and Beyond

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月15日

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  • Anuja Mitra,
  • Amit Bhambri,
  • Matyas Fehervari,
  • Chetan Parmar

摘要

Background

One-anastomosis gastric bypass (OAGB) has gained global prominence as the third most performed bariatric procedure. Despite evidence of short-term efficacy, long-term outcomes remain understudied.

Methods

This PRISMA-compliant systematic review and meta-analysis evaluated long-term (≥ 5 years) outcomes of OAGB as primary and revisional procedures. Quality assessment and bias evaluation were conducted systematically.

Results

Analysis included 32 studies with 19,125 patients (76% primary OAGB) from 14 countries with mean follow-up of 6.7 years. At five years, mean excess weight loss(EWL) was 75%, increasing to 77% beyond five years. Obesity associated diseases resolution was substantial: type 2 diabetes (80%), obstructive sleep apnea (89%), and hypertension (61%). Complications were minimal: bile reflux (4%), marginal ulceration (2%), and malnutrition (1%). For revisional OAGB, %EWL at five years was 71%. The conversion rate to other bariatric procedures (all RYGB) was reported in 3% of patients following OAGB.

Conclusion

This analysis demonstrates OAGB's effectiveness for sustained weight loss and obesity associated diseases improvement at ≥ 5 years, supporting its role in long-term obesity management as a primary and revisional bariatric intervention.