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Background <p>Dumping syndrome (DS) is a known complication of metabolic and bariatric surgery, most commonly associated with Roux-en-Y gastric bypass (RYGB). While one-anastomosis gastric bypass (OAGB) is increasingly used due to its favorable outcomes, the prevalence and risk factors of DS following this procedure remain underexplored.This study aimed to assess the incidence of DS and identify its potential risk factors among patients who underwent OAGB at a tertiary bariatric center.</p> Methods <p>A retrospective cohort study was conducted on 266 patients who underwent OAGB between May 2022 and May 2023. DS was assessed 12 months postoperatively using Sigstad’s scoring system to assess the incidence of DS and Art’s questionnaire to differentiate between early and late DS. Data on demographics, obesity-related medical problems, body mass index (BMI) changes, and other clinical parameters were collected. Binary logistic regression analysis was used to determine predictors of DS.</p> Results <p>The prevalence of DS was 20.7% at 1-year post-OAGB. Among those affected, 53% had early DS, 33% late DS, and 12.5% both types. Mean BMI decreased from 45.8 ± 5.9 to 29.9 ± 4.1 kg/m2, with a total weight loss percentage(TWL%) of 34.4 ± 7.2%. Age (OR = 0.969, <i>p</i> = 0.032) and dyslipidemia (DLP) (OR = 0.405, <i>p</i> = 0.050) were significant negative predictors of DS following OAGB, indicating a lower incidence with increasing age and in patients with DLP. No significant association was found between DS and sex, BMI, type 2 diabetes mellitus (T2DM), hypertension(HTN), or cholecystectomy. Additionally, DS presence was not significantly correlated with weight loss outcomes.</p> Conclusion <p>DS affects approximately one in five patients 1 year following OAGB, with early DS being more prevalent than late. Increasing age and the presence of DLP appear to reduce the risk. Given its impact on patient diet modification, the syndrome does not appear to enhance postoperative weight loss.</p>

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Incidence and Risk Factors of Dumping Syndrome After One-Anastomosis Gastric Bypass (OAGB)

  • 期刊论文

  • 发表日期：

    2025年10月7日

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  • Taher Teimoury,
  • Masoumeh Shahsavan,
  • Shahab Shahab Shahabi Shahmiri,
  • Elham Molaei Nejad,
  • Fahime Yarigholi,
  • Mohammad Kermansaravi

摘要

Background

Dumping syndrome (DS) is a known complication of metabolic and bariatric surgery, most commonly associated with Roux-en-Y gastric bypass (RYGB). While one-anastomosis gastric bypass (OAGB) is increasingly used due to its favorable outcomes, the prevalence and risk factors of DS following this procedure remain underexplored.This study aimed to assess the incidence of DS and identify its potential risk factors among patients who underwent OAGB at a tertiary bariatric center.

Methods

A retrospective cohort study was conducted on 266 patients who underwent OAGB between May 2022 and May 2023. DS was assessed 12 months postoperatively using Sigstad’s scoring system to assess the incidence of DS and Art’s questionnaire to differentiate between early and late DS. Data on demographics, obesity-related medical problems, body mass index (BMI) changes, and other clinical parameters were collected. Binary logistic regression analysis was used to determine predictors of DS.

Results

The prevalence of DS was 20.7% at 1-year post-OAGB. Among those affected, 53% had early DS, 33% late DS, and 12.5% both types. Mean BMI decreased from 45.8 ± 5.9 to 29.9 ± 4.1 kg/m2, with a total weight loss percentage(TWL%) of 34.4 ± 7.2%. Age (OR = 0.969, p = 0.032) and dyslipidemia (DLP) (OR = 0.405, p = 0.050) were significant negative predictors of DS following OAGB, indicating a lower incidence with increasing age and in patients with DLP. No significant association was found between DS and sex, BMI, type 2 diabetes mellitus (T2DM), hypertension(HTN), or cholecystectomy. Additionally, DS presence was not significantly correlated with weight loss outcomes.

Conclusion

DS affects approximately one in five patients 1 year following OAGB, with early DS being more prevalent than late. Increasing age and the presence of DLP appear to reduce the risk. Given its impact on patient diet modification, the syndrome does not appear to enhance postoperative weight loss.