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Background <p>The duodenal-jejunal bypass liner (DJBL) is a treatment for weight loss and diabetes management. While its short-term benefits are known, long-term outcomes of this endoscopic procedure remain largely unknown. This study investigates the long-term effects of DJBL placement on weight, diabetes, and quality of life (QoL) over a period of approximately 10&#xa0;years post-explantation.</p> Methods <p>A cross-sectional follow-up study was conducted in 103 former DJBL patients who had DJBL implantation (also known as the Endobarrier) between 2011 and 2014. Participants completed a questionnaire assessing their health, weight, lifestyle, diabetes control, and QoL. Data were compared to original cohort results.</p> Results <p>After approximately 10&#xa0;years, weight, BMI, and HbA1c levels remained significantly improved compared to the time of DJBL explantation (p &lt; 0.05). Of the respondents, 33 (32%) had undergone metabolic bariatric surgery (MBS) post-explantation, with significant reductions in weight and BMI observed in this group. MBS was associated with better diabetes control and higher QoL scores compared to non-MBS patients. No significant differences in diabetes-related complications were seen between the MBS and non-MBS groups. GLP-1 agonists use was associated with a higher BMI but did not significantly affect weight, diabetes control, or QoL outcomes.</p> Conclusions <p>Although DJBL treatment has some sustained benefits regarding weight and diabetes management, these effects are limited without further weight-reducing interventions. MBS following DJBL explantation leads to more substantial weight loss and improved diabetes outcome, highlighting its complementary role after DJBL treatment.</p>

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Ten Year Follow-Up After Explantation of the Duodenal-jejunal Bypass Liner

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月26日

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  • Fenna M. M. Beeren,
  • Marcel J. M. Groenen,
  • Eric J. Hazebroek,
  • Peter D. Siersema

摘要

Background

The duodenal-jejunal bypass liner (DJBL) is a treatment for weight loss and diabetes management. While its short-term benefits are known, long-term outcomes of this endoscopic procedure remain largely unknown. This study investigates the long-term effects of DJBL placement on weight, diabetes, and quality of life (QoL) over a period of approximately 10 years post-explantation.

Methods

A cross-sectional follow-up study was conducted in 103 former DJBL patients who had DJBL implantation (also known as the Endobarrier) between 2011 and 2014. Participants completed a questionnaire assessing their health, weight, lifestyle, diabetes control, and QoL. Data were compared to original cohort results.

Results

After approximately 10 years, weight, BMI, and HbA1c levels remained significantly improved compared to the time of DJBL explantation (p < 0.05). Of the respondents, 33 (32%) had undergone metabolic bariatric surgery (MBS) post-explantation, with significant reductions in weight and BMI observed in this group. MBS was associated with better diabetes control and higher QoL scores compared to non-MBS patients. No significant differences in diabetes-related complications were seen between the MBS and non-MBS groups. GLP-1 agonists use was associated with a higher BMI but did not significantly affect weight, diabetes control, or QoL outcomes.

Conclusions

Although DJBL treatment has some sustained benefits regarding weight and diabetes management, these effects are limited without further weight-reducing interventions. MBS following DJBL explantation leads to more substantial weight loss and improved diabetes outcome, highlighting its complementary role after DJBL treatment.