Scholarlink

Background <p>Perioperative antibiotic prophylaxis (PAP) prior to laparoscopic gastric bypass surgery is still under debate due to a lack of high evidence. Thus, the study at hand aimed to find out whether this medication lowers the rate of postoperative complications or not.</p> Methods <p>In 2020, a retrospective analysis took place at Helios Hospital Berlin Buch, Germany. The data of patients who underwent laparoscopic Roux-Y gastric bypass (LRYGB) surgery between December 2019 and December 2020 were consecutively enrolled. Individuals who received a PAP (PAP +) were compared with those who did not receive this medication (PAP −). Primary objective was the rate of postoperative complications.</p> Results <p>A total of 494 patients’ charts were analyzed. The mean age was 39.7 (± 12.1) years. The body mass index was on average 46.4 (± 6.5) kg/m<sup>2</sup>. Among these individuals, 259 patients received a PAP and 235 did not. In terms of baseline characteristics and perioperative data, no significant differences were revealed between both groups. A total of 7 surgical site infections (SSI, all grade III) were diagnosed. Patients in the PAP + group had less SSI, (PAP + group, <i>n</i> = 2 (0.8%) vs. PAP- group, <i>n</i> = 5 (2.1%), <i>p</i> = 0.27). Individuals in the PAP + group stayed a shorter time in hospital (PAP + group, 3.83 (± 0.89) days vs. PAP − group, 4.34 (± 3.05) days; <i>p</i> &lt; 0.005). In a multivariate analysis, no administration of PAP was not identified as an independent risk factor for the occurrence of a SSI Grade III (administration of PAP, odds ratio of 0.28 (<i>CI</i> 0.08–1.04), <i>p</i> = 0.058). The PAP administration did not affect the rate of the overall postoperative complication rate (odds ratio of 0.61 (<i>CI</i> 0.32–1.15), <i>p</i> = 0.13).</p> Conclusion <p>In LRYGB, with linear anastomosis, PAP did not significantly reduce SSIs or complications, although a potential benefit in high-risk subgroups (e.g., smokers, patients with diabetes, or high <i>BMI</i>) cannot be excluded.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Impact of Perioperative Antibiotic Prophylaxis on Surgical Site Infections in Laparoscopic Gastric Bypass Surgery: A Single Center Analysis Among 494 Patients

  • 期刊论文

  • 发表日期：

    2025年9月9日

查看全文
  • Gianluca De Santo,
  • Oliver Stumpf,
  • Richard Hunger,
  • Peter Look,
  • Marc Abdelmalek,
  • Michael Hünerbein,
  • Rene Mantke,
  • Christoph Paasch

摘要

Background

Perioperative antibiotic prophylaxis (PAP) prior to laparoscopic gastric bypass surgery is still under debate due to a lack of high evidence. Thus, the study at hand aimed to find out whether this medication lowers the rate of postoperative complications or not.

Methods

In 2020, a retrospective analysis took place at Helios Hospital Berlin Buch, Germany. The data of patients who underwent laparoscopic Roux-Y gastric bypass (LRYGB) surgery between December 2019 and December 2020 were consecutively enrolled. Individuals who received a PAP (PAP +) were compared with those who did not receive this medication (PAP −). Primary objective was the rate of postoperative complications.

Results

A total of 494 patients’ charts were analyzed. The mean age was 39.7 (± 12.1) years. The body mass index was on average 46.4 (± 6.5) kg/m2. Among these individuals, 259 patients received a PAP and 235 did not. In terms of baseline characteristics and perioperative data, no significant differences were revealed between both groups. A total of 7 surgical site infections (SSI, all grade III) were diagnosed. Patients in the PAP + group had less SSI, (PAP + group, n = 2 (0.8%) vs. PAP- group, n = 5 (2.1%), p = 0.27). Individuals in the PAP + group stayed a shorter time in hospital (PAP + group, 3.83 (± 0.89) days vs. PAP − group, 4.34 (± 3.05) days; p < 0.005). In a multivariate analysis, no administration of PAP was not identified as an independent risk factor for the occurrence of a SSI Grade III (administration of PAP, odds ratio of 0.28 (CI 0.08–1.04), p = 0.058). The PAP administration did not affect the rate of the overall postoperative complication rate (odds ratio of 0.61 (CI 0.32–1.15), p = 0.13).

Conclusion

In LRYGB, with linear anastomosis, PAP did not significantly reduce SSIs or complications, although a potential benefit in high-risk subgroups (e.g., smokers, patients with diabetes, or high BMI) cannot be excluded.

Graphical Abstract