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Aim <p>Patients with obesity present with a proinflammatory state generally quantified by measuring acute-phase proteins (APP) such as C reactive protein (CPR) which shows however great variability. The determination of glycoproteins by using MRI spectroscopy, specifically acetyl groups of N-acetylglucosamine and N-acetylgalactosamine (GlycA), and acetyl groups of N-acetylneuraminic acid (GlycB), allows us to measure the aforementioned proinflammatory state with less interindividual variability than other biomarkers such as CPR, high-sensitivity CPR (hsCPR), or IL-6. The aim of this study is to show the influence of metabolic surgery over highly sensitive inflammatory markers (GlycA, Glyc B, and Glyc F).</p> Material and Methods <p>This prospective observational study included 52 patients undergoing metabolic surgery. Plasma levels of GlycA, GlycB, GlycF, and ratios HWGlycA and HWGlycB were measured before and 18&#xa0;months after surgery.</p> Results <p>The cohort had a mean age of 46.3&#xa0;years, 63.5% were women, with a mean BMI of 43.6&#xa0;kg/m<sup>2</sup>, and abdominal circumference of 133.5&#xa0;cm. Surgical techniques included BRYGB (55.7%), RYGB (19.2%), and SG (17.3%). GlycA decreased significantly postoperatively (mean difference: − 79.3 units; Cohen’s <i>d</i> = 1.99), as did GlycB (− 35.9; <i>d</i> = 1.88) and GlycF (− 43.7; <i>d</i> = 2.22), with all <i>p</i> &lt; 0.001.</p> Conclusions <p>Metabolic surgery significantly reduces the proinflammatory state in patients with obesity, as demonstrated by large effect sizes and reductions in NMR-measured glycoproteins. These markers may offer a reliable method to monitor inflammation beyond traditional acute-phase reactants.</p>

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Glycoprotein Determination with NMR Spectroscopy to Evaluate the Effect of Metabolic Surgery over the Proinflammatory State of Patients with Obesity

  • 期刊论文

  • 发表日期：

    2025年8月7日

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  • Mercedes Bernaldo de Quirós Fernández,
  • Elías Rodríguez Cuellar,
  • Blanca Otero Torrón,
  • Nuria Amigó,
  • Eduardo Ferrero Herrero,
  • Cristina Martín-Arriscado Arroba,
  • Ana Isabel Pérez Zapata

摘要

Aim

Patients with obesity present with a proinflammatory state generally quantified by measuring acute-phase proteins (APP) such as C reactive protein (CPR) which shows however great variability. The determination of glycoproteins by using MRI spectroscopy, specifically acetyl groups of N-acetylglucosamine and N-acetylgalactosamine (GlycA), and acetyl groups of N-acetylneuraminic acid (GlycB), allows us to measure the aforementioned proinflammatory state with less interindividual variability than other biomarkers such as CPR, high-sensitivity CPR (hsCPR), or IL-6. The aim of this study is to show the influence of metabolic surgery over highly sensitive inflammatory markers (GlycA, Glyc B, and Glyc F).

Material and Methods

This prospective observational study included 52 patients undergoing metabolic surgery. Plasma levels of GlycA, GlycB, GlycF, and ratios HWGlycA and HWGlycB were measured before and 18 months after surgery.

Results

The cohort had a mean age of 46.3 years, 63.5% were women, with a mean BMI of 43.6 kg/m2, and abdominal circumference of 133.5 cm. Surgical techniques included BRYGB (55.7%), RYGB (19.2%), and SG (17.3%). GlycA decreased significantly postoperatively (mean difference: − 79.3 units; Cohen’s d = 1.99), as did GlycB (− 35.9; d = 1.88) and GlycF (− 43.7; d = 2.22), with all p < 0.001.

Conclusions

Metabolic surgery significantly reduces the proinflammatory state in patients with obesity, as demonstrated by large effect sizes and reductions in NMR-measured glycoproteins. These markers may offer a reliable method to monitor inflammation beyond traditional acute-phase reactants.