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<p>This commentary critiques the statistical framing and clinical implications of Ramos et al.’s meta-analysis comparing one-anastomosis and Roux-en-Y gastric bypass. While OAGB shows non-inferiority for type 2 diabetes remission under select conditions, its elevated risk of bile reflux and GERD limits its broad applicability. We emphasize the need for consistent non-inferiority thresholds and patient-specific surgical planning.</p>

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Comment on “One-Anastomosis Versus Roux-en-Y Gastric Bypass in the Resolution of Comorbidities: A Non-inferiority Meta-analysis and Meta-regression”

  • 期刊论文

  • 发表日期：

    2025年8月4日

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  • Nitin R Nangare,
  • Akash Katkar,
  • Koyel Roy

摘要

This commentary critiques the statistical framing and clinical implications of Ramos et al.’s meta-analysis comparing one-anastomosis and Roux-en-Y gastric bypass. While OAGB shows non-inferiority for type 2 diabetes remission under select conditions, its elevated risk of bile reflux and GERD limits its broad applicability. We emphasize the need for consistent non-inferiority thresholds and patient-specific surgical planning.