Background <p>Hyperuricemia is a metabolic disorder associated with obesity. Many studies have reported the effect of bariatric surgery on the decrease of serum uric acid level in patients with hyperuricemia. However, since the update of diagnostic criteria of hyperuricemia, the correlation between preoperative body mass index, postoperative weight changes, and the remission of hyperuricemia in patients with obesity after sleeve gastrectomy requires consensus.</p> Methods <p>One hundred and ninety-three patients with obesity and hyperuricemia who underwent laparoscopic sleeve gastrectomy were enrolled. All patients were followed up for 6&#xa0;months postoperatively. Subgroup analysis was performed using the tertiles of preoperative body mass index, total weight loss, and excess weight loss to investigate the correlation with the remission of hyperuricemia after sleeve gastrectomy.</p> Results <p>A total of 193 patients were included in this study. Among them, 123 patients were female and 70 were male. And the mean age was 30.2 ± 7.8&#xa0;years, preoperative body weight was 116.1 ± 23.3&#xa0;kg, and the preoperative BMI was 40.5 ± 6.7&#xa0;kg/m². 59.1% (114/193) patients achieved remission of hyperuricemia 6&#xa0;months after sleeve gastrectomy. The TWL% and EWL% were 25.6% ± 5.4% and 75.9% ± 28.2%, respectively. Female patients had a significantly higher remission rate than that of male patients (<i>p</i> &lt; 0.05). Correlations were found between EWL%/preoperative BMI with the remission of hyperuricemia (<i>p</i> &lt; 0.05).</p> Conclusion <p>Sleeve gastrectomy had a positive effect on the remission of hyperuricemia in patients with obesity. EWL% may play a significant role in the remission of hyperuricemia.</p>