Long-Term Weight Loss Outcomes of One Anastomosis Gastric Bypass: Assessment of 1971 Patients with 5–9-Year Follow-Up

While OAGB shows promise in the short to medium term, its long-term durability, weight trends, blood levels of metabolic factors and nutrients, and potential complications require further exploration through larger, longer-term studies. This study contributes to the growing body of evidence by reporting on the long-term outcomes of patients with severe obesity who underwent OAGB.

A retrospective study on prospectively collected data was conducted on a sample of 1917 patients who underwent OAGB between 2010 and 2019 and had a BMI ≥ 35 kg/m². The data required for the study were obtained from our national registry database of obesity surgery (INOSD).

In total, 1971 patients were included, with 1474 (74.8%) female predominance. The mean age and BMI before surgery were 40.31 ± 11.21 years (range 18 to 75 years) and 46.68 ± 6.7 kg/m² (range 35–86.57 kg/m²), respectively. The mean biliopancreatic limb length was 185.02 ± 15.61 cm. Our follow-up rate was 96.19% and 75.85% in 24 and 60 months after OAGB, respectively. %TWL and %EWL reached the maximum 18 months after the operation (36.49 ± 7.77, 81.54 ± 19.18, respectively). Suboptimal initial weight loss (SIWL) 2 years after surgery was 2.9%, and TWL less than 20% and EWL less than 50% were calculated at 5-year follow-up, which was 10.2% and 14.8%, respectively.

The results of this study indicate that OAGB has acceptable long-term effects on weight loss and the remission or improvement of obesity-related medical conditions.