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<p>Antibacterial hydrogels show promising applications in medicine, pharmaceuticals, and tissue engineering. This study developed chitosan nanoparticles (CNPs), a natural antimicrobial agent, via ionotropic gelation with sodium tripolyphosphate (TPP). Results indicated that using obtained optimum amounts of 0.2% (W/V) chitosan (14.4 mL) and 0.5% (W/V) TPP (0.42 mL), spherical and monodispersed colloidal CNPs with particle size of 10&#xa0;nm, polydispersity index (PDI) of 0.384, color intensity of 0.06% a.u. (absorbance unit), turbidity of 0.05% a.u., and zeta potential of 35.7 mV, were synthesized. These formed CNPs exhibited high bactericidal activity against to four selected Gram-positive and Gram-negative foodborne pathogens. Subsequently, nanohydrogel was fabricated using colloidal CNPs via lyophilization and characterized. Results demonstrated that the formed hydrogel had semi-crystalline porous structure with equilibrium swelling, water absorption, degradation rate and porosity of 67.6%, 3.38&#xa0;g, 6%, and 57.7%, respectively. Thermal analysis revealed that the prepared hydrogel had melting point and enthalpy of 122.3&#xa0;°C and − 412.9&#xa0;J/g, respectively. Finally, curcumin was loaded in the produced hydrogel and its releasing from the hydrogel was evaluated and result indicated that it was fitted to Korsmeyer–Peppas model with K and n of 2.17 and 0.3, respectively. Furthermore, prepared hydrogel containing curcumin exhibited potent antibacterial activity against several bacterial strains, which that enhanced its potential as a natural preservative in the food formulation, especially fruit juices and dairy products.</p> Graphical abstract <p></p>

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Nanohydrogel based on chitosan nanoparticles and lyophilization technique: Preparation, characterization antibacterial activity and curcumin release assessment

  • 期刊论文

  • 发表日期：

    2026年7月9日

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  • Sahel Sharghi,
  • Hoda Jafarizadeh-Malmiri,
  • Parizad Allahverdikhan Vaziri

摘要

Antibacterial hydrogels show promising applications in medicine, pharmaceuticals, and tissue engineering. This study developed chitosan nanoparticles (CNPs), a natural antimicrobial agent, via ionotropic gelation with sodium tripolyphosphate (TPP). Results indicated that using obtained optimum amounts of 0.2% (W/V) chitosan (14.4 mL) and 0.5% (W/V) TPP (0.42 mL), spherical and monodispersed colloidal CNPs with particle size of 10 nm, polydispersity index (PDI) of 0.384, color intensity of 0.06% a.u. (absorbance unit), turbidity of 0.05% a.u., and zeta potential of 35.7 mV, were synthesized. These formed CNPs exhibited high bactericidal activity against to four selected Gram-positive and Gram-negative foodborne pathogens. Subsequently, nanohydrogel was fabricated using colloidal CNPs via lyophilization and characterized. Results demonstrated that the formed hydrogel had semi-crystalline porous structure with equilibrium swelling, water absorption, degradation rate and porosity of 67.6%, 3.38 g, 6%, and 57.7%, respectively. Thermal analysis revealed that the prepared hydrogel had melting point and enthalpy of 122.3 °C and − 412.9 J/g, respectively. Finally, curcumin was loaded in the produced hydrogel and its releasing from the hydrogel was evaluated and result indicated that it was fitted to Korsmeyer–Peppas model with K and n of 2.17 and 0.3, respectively. Furthermore, prepared hydrogel containing curcumin exhibited potent antibacterial activity against several bacterial strains, which that enhanced its potential as a natural preservative in the food formulation, especially fruit juices and dairy products.

Graphical abstract