Scholarlink

<p>The search for effective anti-aging interventions, including botanical extracts with bioactive properties, has led to growing interest in natural remedies. <i>Nigella sativa</i> L. (black cumin) has gained attention for its pharmacological benefits. This study assessed the effects of different geographical origins (Egypt, Ethiopia, and Sudan) on the constituents of <i>N. sativa</i> (NS) oils and their anti-aging potentials. Through GC/MS analysis, 13, 9, and 12 bioactive compounds in NS Ethiopia, Sudan, and Egypt were detected, respectively. Fatty acid methyl esters ranged from 67.51% to 85.47%. The major compound in Sudan and Egypt was oleic acid methyl ester (37.82% and 32.93%), while in Ethiopia, it was stearic methyl ester (36.42%). Results showed significant variations in enzyme inhibitory activity among the oils. Sudan NS oil surpassed the reference standard in its ability to inhibit collagenase, elastase, hyaluronidase, and tyrosinase with IC<sub>50</sub> values of 37.16 ± 1.26, 27.14 ± 0.92, 36.29 ± 1.53, and 10.78 ± 0.46, respectively. The Ethiopian variant showed the lowest activity in most assays except for anti-elastase. In-silico molecular docking confirmed the compounds’ favorable drug-like properties. The chemical makeups of the samples were effectively differentiated by region of collection through Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA). The results suggest the potential of <i>Nigella sativa</i> oil, particularly the Sudanese variety as a natural candidate for incorporation into anti-aging formulations. Additional studies are needed to better understand the underlying mechanisms and improve the use of black seed oil as a natural anti-aging agent in medicinal applications and the cosmetic industry.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Measurement-based comparative assessment of anti-aging and antioxidant properties of Nigella sativa oils extracted by supercritical fluids from different origins

  • 期刊论文

  • 发表日期：

    2026年3月20日

查看全文
  • Noha Khalil,
  • Haidy A. Gad,
  • Asmaa A. Mandour,
  • Eman R. Elsharkawy,
  • Mokhtar M. Bishr,
  • Mohamed L. Ashour,
  • Yasmin A. Elkhawas

摘要

The search for effective anti-aging interventions, including botanical extracts with bioactive properties, has led to growing interest in natural remedies. Nigella sativa L. (black cumin) has gained attention for its pharmacological benefits. This study assessed the effects of different geographical origins (Egypt, Ethiopia, and Sudan) on the constituents of N. sativa (NS) oils and their anti-aging potentials. Through GC/MS analysis, 13, 9, and 12 bioactive compounds in NS Ethiopia, Sudan, and Egypt were detected, respectively. Fatty acid methyl esters ranged from 67.51% to 85.47%. The major compound in Sudan and Egypt was oleic acid methyl ester (37.82% and 32.93%), while in Ethiopia, it was stearic methyl ester (36.42%). Results showed significant variations in enzyme inhibitory activity among the oils. Sudan NS oil surpassed the reference standard in its ability to inhibit collagenase, elastase, hyaluronidase, and tyrosinase with IC50 values of 37.16 ± 1.26, 27.14 ± 0.92, 36.29 ± 1.53, and 10.78 ± 0.46, respectively. The Ethiopian variant showed the lowest activity in most assays except for anti-elastase. In-silico molecular docking confirmed the compounds’ favorable drug-like properties. The chemical makeups of the samples were effectively differentiated by region of collection through Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA). The results suggest the potential of Nigella sativa oil, particularly the Sudanese variety as a natural candidate for incorporation into anti-aging formulations. Additional studies are needed to better understand the underlying mechanisms and improve the use of black seed oil as a natural anti-aging agent in medicinal applications and the cosmetic industry.