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<p><i>Melissa officinalis</i>, commonly known as lemon balm, is a traditional medicinal herb renowned for its diverse bioactivities linked to its rich secondary metabolite profile. In this study, the phenolic compounds of <i>M. officinalis</i> were profiled using ultra-performance liquid chromatography coupled with quadrupole time-of-flight electrospray ionization tandem mass spectrometry (UPLC-QTOF-ESI-MS/MS) and quantified using high-performance liquid chromatography with photodiode array detection (HPLC-PDA). The compounds identified included hydroxycinnamic acids (chlorogenic acid and ferulic acid) and flavonoids (luteolin, apigenin, and their glycosylated derivatives). Caftaric acid (<b>1</b>), caffeic acid (<b>2</b>), isorhoifolin (<b>3</b>), rosmarinic acid (<b>4</b>), lithospermic acid (<b>5</b>), and schizotenuin A (<b>6</b>) were quantified. Among these, rosmarinic acid (<b>4</b>) exhibited the highest concentration at 213.75&#xa0;mg/g extract, whereas isorhoifolin (<b>3</b>) and lithospermic acid (<b>5</b>) were not detected. These results provide valuable reference points for quality control and product standardization. The high content of rosmarinic acid (<b>4</b>) and the broad phenolic diversity highlight that <i>M. officinalis</i> is a promising source for herbal, nutraceutical, and cosmetic use.</p>

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Phytochemical profiling and quantification of phenolic compounds in Melissa officinalis using UPLC-QTOF-ESI-MS/MS and HPLC-PDA

  • 期刊论文

  • 发表日期：

    2025年12月12日

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  • Neil Patrick Uy,
  • Hak-Dong Lee,
  • Hye-Jin Kim,
  • Hye-Jeong See,
  • Sanghyun Lee

摘要

Melissa officinalis, commonly known as lemon balm, is a traditional medicinal herb renowned for its diverse bioactivities linked to its rich secondary metabolite profile. In this study, the phenolic compounds of M. officinalis were profiled using ultra-performance liquid chromatography coupled with quadrupole time-of-flight electrospray ionization tandem mass spectrometry (UPLC-QTOF-ESI-MS/MS) and quantified using high-performance liquid chromatography with photodiode array detection (HPLC-PDA). The compounds identified included hydroxycinnamic acids (chlorogenic acid and ferulic acid) and flavonoids (luteolin, apigenin, and their glycosylated derivatives). Caftaric acid (1), caffeic acid (2), isorhoifolin (3), rosmarinic acid (4), lithospermic acid (5), and schizotenuin A (6) were quantified. Among these, rosmarinic acid (4) exhibited the highest concentration at 213.75 mg/g extract, whereas isorhoifolin (3) and lithospermic acid (5) were not detected. These results provide valuable reference points for quality control and product standardization. The high content of rosmarinic acid (4) and the broad phenolic diversity highlight that M. officinalis is a promising source for herbal, nutraceutical, and cosmetic use.