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<p>The ginsenoside compound K (CK) is a derivative that demonstrates exceptional bioactivity and has been proven to possess significant health benefits. However, the predominant ginsenosides present in ginseng can undergo enzymatic hydrolysis or microbial fermentation, leading to the biotransformation of CK through cleavage of the attached sugar moieties within the dammarane skeleton. This study aimed to investigate the optimal conditions for synergistic treatment of <i>Panax ginseng</i> C.A Mayer leaves extract powder (GLEP) through cellulase hydrolysis synergized with a multiple-frequency ultrasound-assisted approach to enhance the content of CK. The ability of GLEP hydrolysis to inhibit the activities of α-glucosidase and β-galactosidase was also evaluated. This study showed that the optimal cellulase dosage of 50&#xa0;mg in combination with multi-frequency ultrasound for 24&#xa0;h hydrolysis effectively enhanced the biotransformation rate of CK by 1.02%. Moreover, the samples’ total polysaccharide content and inhibition rates of α-glucosidase and β-galactosidase activities were significantly increased (<i>p</i> &lt; 0.05) following the synergistic treatment under optimal conditions. Inhibiting α-glucosidase and β-galactosidase have effectively mitigated the rise in postprandial blood glucose levels. This finding suggests a potential mechanism for managing blood sugar spikes following meals. Therefore, this study presents a valuable strategy for specifically targeting the enzyme-hydrolyzed synergized with multiple-frequency ultrasonic assistance approach to enhance the biotransformation of CK.</p>

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Synergistic effects of cellulase hydrolysis and multiplex-frequency ultrasonic-assisted treatment on powder promotion derived from Panax ginseng C.A Mayer leaves: a sustainable biotransformation strategy

  • 期刊论文

  • 发表日期：

    2025年5月16日

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  • Yu-Wen Lin,
  • Min-Fang Tsai,
  • Da-Wei Huang,
  • Ping-Hsiu Huang

摘要

The ginsenoside compound K (CK) is a derivative that demonstrates exceptional bioactivity and has been proven to possess significant health benefits. However, the predominant ginsenosides present in ginseng can undergo enzymatic hydrolysis or microbial fermentation, leading to the biotransformation of CK through cleavage of the attached sugar moieties within the dammarane skeleton. This study aimed to investigate the optimal conditions for synergistic treatment of Panax ginseng C.A Mayer leaves extract powder (GLEP) through cellulase hydrolysis synergized with a multiple-frequency ultrasound-assisted approach to enhance the content of CK. The ability of GLEP hydrolysis to inhibit the activities of α-glucosidase and β-galactosidase was also evaluated. This study showed that the optimal cellulase dosage of 50 mg in combination with multi-frequency ultrasound for 24 h hydrolysis effectively enhanced the biotransformation rate of CK by 1.02%. Moreover, the samples’ total polysaccharide content and inhibition rates of α-glucosidase and β-galactosidase activities were significantly increased (p < 0.05) following the synergistic treatment under optimal conditions. Inhibiting α-glucosidase and β-galactosidase have effectively mitigated the rise in postprandial blood glucose levels. This finding suggests a potential mechanism for managing blood sugar spikes following meals. Therefore, this study presents a valuable strategy for specifically targeting the enzyme-hydrolyzed synergized with multiple-frequency ultrasonic assistance approach to enhance the biotransformation of CK.