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<p>Using a protein based phylogeny built from mass spectral mass map data, it is shown for the first time that the evolutionary trajectory of SARS-CoV-2 virus variants can be accurately projected from the originating strain of 2019 through to those of the present day. Further, in the same single tree building step, these datasets enable single point mutations within the surface spike protein to be calculated and displayed along branches of the tree so the virus’ mutation history can also be followed. It is demonstrated that this strategy, which avoids sequence generation and alignment, can be rapidly implemented using datasets commonly employed in protein identification and proteomics applications. It provides an alternate, complementary approach that avoids obstacles encountered in conventional phylogenetics in the study of rapidly evolving, pandemic-causing, respiratory viruses. The approach has broad applicability for the study of any organism from a protein evolution perspective.</p>

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Evolution and Mutation Trajectory of the SARS-CoV-2 Coronavirus with Mass Spectrometry

  • 期刊论文

  • 发表日期：

    2025年6月24日

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  • Matthew Wright,
  • Kevin M. Downard

摘要

Using a protein based phylogeny built from mass spectral mass map data, it is shown for the first time that the evolutionary trajectory of SARS-CoV-2 virus variants can be accurately projected from the originating strain of 2019 through to those of the present day. Further, in the same single tree building step, these datasets enable single point mutations within the surface spike protein to be calculated and displayed along branches of the tree so the virus’ mutation history can also be followed. It is demonstrated that this strategy, which avoids sequence generation and alignment, can be rapidly implemented using datasets commonly employed in protein identification and proteomics applications. It provides an alternate, complementary approach that avoids obstacles encountered in conventional phylogenetics in the study of rapidly evolving, pandemic-causing, respiratory viruses. The approach has broad applicability for the study of any organism from a protein evolution perspective.