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Purpose <p><i>Dioscorea</i><i> dumetorum</i> (locally known as <i>Esuru</i> {Yoruba tribe of Nigeria}) has been claimed to be used in folk medicine for the management of malaria without information on the anti-plasmodial rich fraction. It is against this background that the current study was designed to provide information on the anti-plasmodial rich fraction of <i>Dioscorea dumetorium</i> tubers. </p> Methods <p>The n-hexane (nHF), ethylacetate (EAF), and n-butanol (nBF) fractions obtained from <i>D. dumetorum</i> tubers were screened for anti-plasmodial activity. The most potent fraction, nBF, was further subjected to column chromatography and the resulting three sub-fractions (CCF1-CCF3) were equally screened for anti-plasmodial activity. The most potent sub-fraction, CCF1, was chemically profiled using HPLC. </p> Results <p>The results revealed that the nBF and CCF1 demonstrated the most profound inhibition (<i>p</i> &lt; 0.05) of parasite growth by 49.13% and 40.80% respectively. The CCF1contained 11 chemical compounds with allantoin and protodioscin being relatively the most abundant. The significant and dose-dependent suppression of parasitemia by the n-BF and its CCF1 in the murine model conferred potent anti-plasmodial activity on them. </p> Conclusion <p>In conclusion, the nBF and CCF1 from the <i>D. dumetorum</i> tubers represents a promising and pharmacologically relevant source for the development of novel antimalarial therapies or lead compounds.</p>

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n-Butanol Fraction of Dioscorea dumetorum Tuber Aqueous Extract Exhibited Potent Antimalarial Activity in Plasmodium berghei-infected Mice

  • 期刊论文

  • 发表日期：

    2025年12月18日

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  • U. Okeme,
  • M. T. Yakubu

摘要

Purpose

Dioscorea dumetorum (locally known as Esuru {Yoruba tribe of Nigeria}) has been claimed to be used in folk medicine for the management of malaria without information on the anti-plasmodial rich fraction. It is against this background that the current study was designed to provide information on the anti-plasmodial rich fraction of Dioscorea dumetorium tubers.

Methods

The n-hexane (nHF), ethylacetate (EAF), and n-butanol (nBF) fractions obtained from D. dumetorum tubers were screened for anti-plasmodial activity. The most potent fraction, nBF, was further subjected to column chromatography and the resulting three sub-fractions (CCF1-CCF3) were equally screened for anti-plasmodial activity. The most potent sub-fraction, CCF1, was chemically profiled using HPLC.

Results

The results revealed that the nBF and CCF1 demonstrated the most profound inhibition (p < 0.05) of parasite growth by 49.13% and 40.80% respectively. The CCF1contained 11 chemical compounds with allantoin and protodioscin being relatively the most abundant. The significant and dose-dependent suppression of parasitemia by the n-BF and its CCF1 in the murine model conferred potent anti-plasmodial activity on them.

Conclusion

In conclusion, the nBF and CCF1 from the D. dumetorum tubers represents a promising and pharmacologically relevant source for the development of novel antimalarial therapies or lead compounds.