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<p>Migraine is a common neurological condition, with episodic migraine being the most prevalent subtype. Chronification of migraine is an important marker of disease progression, and increasing attack frequency is a key predictor of the transformation from migraine with episodic characteristics to chronic migraine. Alterations in the function of the nucleus accumbens (NAc) have been identified as contributing factors to the pathophysiology of migraine, particularly in cases of chronic migraine. However, it remains unclear from neuroimaging studies whether aberrant functional connectivity (FC) networks of the NAc contribute to worsening disability in migraine patients by promoting increased attack frequency. In this current research, we conducted voxel-wise FC analyses using the NAc as the seed to explore the relationships among migraine attack frequency, disability severity, and the NAc-FC network. This study included 31 healthy controls (HCs), 37 low-frequency episodic migraine (LFEM) patients, and 21 high-frequency episodic migraine (HFEM) patients. Participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans and were administered a series of psychological scales. FC networks were created using bilateral NAc as seeds, followed by the analysis of group differences. Furthermore, partial correlation analysis was employed to explore the link between the NAc-FC network and migraine features. Analysis of the NAc-based FC networks revealed significant group differences in specific brain regions, including in the left middle occipital gyrus (MOG) and inferior parietal lobule (IPL), as well as the right caudate nucleus (CN). Relative to the HC and LFEM groups, the HFEM group showed increased left NAc–left MOG connectivity but reduced left NAc–left IPL connectivity. Furthermore, this group displayed significantly stronger right NAc–right CN connectivity. In the combined migraine cohort, left NAc–left MOG connectivity was positively associated with attack frequency. Conversely, left NAc–left IPL connectivity correlated positively with attack duration but negatively with attack frequency. Furthermore, right NAc–right CN connectivity was positively correlated with both attack frequency and Migraine Disability Assessment (MIDAS) scores. Alterations in the NAc-FC network correlate with both the attack frequency and the severity of disability. These findings furnish neuroimaging evidence for the pathways that contribute to migraine chronicity and present therapeutic strategies for preventing its chronic development.</p>

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Abnormal functional connectivity networks in the nucleus accumbens correlate with migraine attack frequency and disability

  • 期刊论文

  • 发表日期：

    2026年3月27日

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  • YingSheng Zhang,
  • ChangLin Wang,
  • Wei Gui,
  • XiaoJun Feng,
  • ZongJin Yun,
  • YongTao Yu,
  • Bin Song,
  • Hong Kan,
  • Shuai Miao,
  • Yu Wang

摘要

Migraine is a common neurological condition, with episodic migraine being the most prevalent subtype. Chronification of migraine is an important marker of disease progression, and increasing attack frequency is a key predictor of the transformation from migraine with episodic characteristics to chronic migraine. Alterations in the function of the nucleus accumbens (NAc) have been identified as contributing factors to the pathophysiology of migraine, particularly in cases of chronic migraine. However, it remains unclear from neuroimaging studies whether aberrant functional connectivity (FC) networks of the NAc contribute to worsening disability in migraine patients by promoting increased attack frequency. In this current research, we conducted voxel-wise FC analyses using the NAc as the seed to explore the relationships among migraine attack frequency, disability severity, and the NAc-FC network. This study included 31 healthy controls (HCs), 37 low-frequency episodic migraine (LFEM) patients, and 21 high-frequency episodic migraine (HFEM) patients. Participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans and were administered a series of psychological scales. FC networks were created using bilateral NAc as seeds, followed by the analysis of group differences. Furthermore, partial correlation analysis was employed to explore the link between the NAc-FC network and migraine features. Analysis of the NAc-based FC networks revealed significant group differences in specific brain regions, including in the left middle occipital gyrus (MOG) and inferior parietal lobule (IPL), as well as the right caudate nucleus (CN). Relative to the HC and LFEM groups, the HFEM group showed increased left NAc–left MOG connectivity but reduced left NAc–left IPL connectivity. Furthermore, this group displayed significantly stronger right NAc–right CN connectivity. In the combined migraine cohort, left NAc–left MOG connectivity was positively associated with attack frequency. Conversely, left NAc–left IPL connectivity correlated positively with attack duration but negatively with attack frequency. Furthermore, right NAc–right CN connectivity was positively correlated with both attack frequency and Migraine Disability Assessment (MIDAS) scores. Alterations in the NAc-FC network correlate with both the attack frequency and the severity of disability. These findings furnish neuroimaging evidence for the pathways that contribute to migraine chronicity and present therapeutic strategies for preventing its chronic development.