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<p>Tinnitus, characterized by phantom sound perception, exhibits heterogeneous pathophysiology influenced by hearing status. This study investigated dynamic neural activity patterns in 82 participants: 29 healthy controls (HC), 21 tinnitus patients with normal hearing (G1), and 32 tinnitus patients with hearing impairment (G2). Using resting-state fMRI, we computed dynamic amplitude of low-frequency fluctuation (d-ALFF) and dynamic regional homogeneity (d-ReHo) through sliding-window analyses, measuring temporal variability via coefficient of variation. One-way ANOVAs (covarying age/sex) revealed six d-ALFF clusters showing group differences (voxel <i>p</i> &lt; 0.01, cluster <i>p</i> &lt; 0.05 GRF-corrected). Post-hoc analyses demonstrated that G1 exhibited significantly increased d-ALFF variability versus HC and G2 in cerebellar, fusiform, and occipital regions. Conversely, both patient groups showed reduced d-ALFF variability in frontal clusters versus HC. Negative correlations emerged in G2 between fusiform d-ALFF and tinnitus distress/anxiety, while G1 showed positive correlations between temporal d-ALFF and depression. d-ReHo analysis identified reduced variability in the right anterior cingulate in both patient groups versus HC. These findings highlight distinct neural dynamics: tinnitus with normal hearing involves hypervariability in sensory processing regions, while hearing-impaired tinnitus shows distinct clinical correlations. Reduced activity variability in the superior and middle frontal gyri and reduced temporal synchrony in the anterior cingulate suggest a common tinnitus mechanism irrespective of hearing status.</p>

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Neural dynamics in tinnitus: differential effects of hearing status on temporal brain activity variability

  • 期刊论文

  • 发表日期：

    2026年3月4日

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  • Haoliang Du,
  • Xiaoyun Qian,
  • Xia Gao,
  • Chenjie Yu,
  • Junguo Wang,
  • Ao Li,
  • Yajun Gu,
  • Xu Feng

摘要

Tinnitus, characterized by phantom sound perception, exhibits heterogeneous pathophysiology influenced by hearing status. This study investigated dynamic neural activity patterns in 82 participants: 29 healthy controls (HC), 21 tinnitus patients with normal hearing (G1), and 32 tinnitus patients with hearing impairment (G2). Using resting-state fMRI, we computed dynamic amplitude of low-frequency fluctuation (d-ALFF) and dynamic regional homogeneity (d-ReHo) through sliding-window analyses, measuring temporal variability via coefficient of variation. One-way ANOVAs (covarying age/sex) revealed six d-ALFF clusters showing group differences (voxel p < 0.01, cluster p < 0.05 GRF-corrected). Post-hoc analyses demonstrated that G1 exhibited significantly increased d-ALFF variability versus HC and G2 in cerebellar, fusiform, and occipital regions. Conversely, both patient groups showed reduced d-ALFF variability in frontal clusters versus HC. Negative correlations emerged in G2 between fusiform d-ALFF and tinnitus distress/anxiety, while G1 showed positive correlations between temporal d-ALFF and depression. d-ReHo analysis identified reduced variability in the right anterior cingulate in both patient groups versus HC. These findings highlight distinct neural dynamics: tinnitus with normal hearing involves hypervariability in sensory processing regions, while hearing-impaired tinnitus shows distinct clinical correlations. Reduced activity variability in the superior and middle frontal gyri and reduced temporal synchrony in the anterior cingulate suggest a common tinnitus mechanism irrespective of hearing status.