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<p>Classical trigeminal neuralgia (CTN) patients often experience impairments in pain perception, emotional cognition, motor function, and regulation. Brain damage in CTN occurs across multiple regions involved in these functions, but the integrity of functional networks remains unclear. This study aimed to explore regional interactions across the entire brain and the complex functional and structural network organization in CTN patients using whole-brain functional connectivity (FC), brain network topological properties and structutal-functional connectivity (SC-FC coupling). We collected resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) data from 32 CTN patients and 30 healthy controls (HC), constructing functional connectivity networks (FCN) and structural connectivity networks (SCN). Whole-brain FC analysis was used to assess interregional FC correlations, while graph-theory analysis and SC-FC coupling were applied to evaluate effects within subnetworks of the FCN and SCN. We also analyzed the correlation between network properties, SC- FC coupling and clinical variables. Compared to HC, the Network-Based Statistic (NBS) revealed that CTN patients exhibited significantly enhanced functional connectivity within a subnetwork composed of 28 nodes and 39 edges (<i>P</i> = 0.0174, NBS corrected). CTN patients showed a randomization pattern of small-world properties in FCN, while SCN exhibited a regularization pattern of small-world properties. The SC-FC coupling was significantly higher in CTN patients compared to HC. Partial correlation analysis found no significant relationship between the subnetwork global properties, SC-FC coupling and clinical variables in CTN patients. Our findings suggest that altered resting-state FC and impaired subnetwork organization may contribute to the functional deficits in CTN. Besides, CTN patients exhibit more severe damage in the SCN, with enhanced SC-FC coupling, likely due to the interaction between white matter microstructure and functional activity, offering new insights into the pathophysiological mechanisms of CTN.</p>

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Disruption of functional and structural topological organization in specific subnetwork among patients with classical trigeminal neuralgia: a graph theory-based magnetic resonance imaging study

  • 期刊论文

  • 发表日期：

    2025年6月24日

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  • Linhua Huang,
  • Meng Li,
  • Yuying Chen,
  • Qianling Zhou,
  • Jinyan Chen,
  • Jianhao Yan

摘要

Classical trigeminal neuralgia (CTN) patients often experience impairments in pain perception, emotional cognition, motor function, and regulation. Brain damage in CTN occurs across multiple regions involved in these functions, but the integrity of functional networks remains unclear. This study aimed to explore regional interactions across the entire brain and the complex functional and structural network organization in CTN patients using whole-brain functional connectivity (FC), brain network topological properties and structutal-functional connectivity (SC-FC coupling). We collected resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) data from 32 CTN patients and 30 healthy controls (HC), constructing functional connectivity networks (FCN) and structural connectivity networks (SCN). Whole-brain FC analysis was used to assess interregional FC correlations, while graph-theory analysis and SC-FC coupling were applied to evaluate effects within subnetworks of the FCN and SCN. We also analyzed the correlation between network properties, SC- FC coupling and clinical variables. Compared to HC, the Network-Based Statistic (NBS) revealed that CTN patients exhibited significantly enhanced functional connectivity within a subnetwork composed of 28 nodes and 39 edges (P = 0.0174, NBS corrected). CTN patients showed a randomization pattern of small-world properties in FCN, while SCN exhibited a regularization pattern of small-world properties. The SC-FC coupling was significantly higher in CTN patients compared to HC. Partial correlation analysis found no significant relationship between the subnetwork global properties, SC-FC coupling and clinical variables in CTN patients. Our findings suggest that altered resting-state FC and impaired subnetwork organization may contribute to the functional deficits in CTN. Besides, CTN patients exhibit more severe damage in the SCN, with enhanced SC-FC coupling, likely due to the interaction between white matter microstructure and functional activity, offering new insights into the pathophysiological mechanisms of CTN.