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<p>Post-menopause is associated with chronic fatigue, inflammation, and aberrant brain connectivity, however there is a dearth of studies comparing these effects as a function of HIV. The current study investigated whether degree centrality of the thalamus mediates the effect of sCD14, a marker of monocyte activation, on fatigue and whether those parameters vary as a function of HIV-status. Resting-state functional connectivity MRI data, blood plasma, and self-report data were collected from 16 HIV + and 25 HIV- post-menopausal women. Analyses tested whether degree centrality of the thalamus, caudate, and right putamen mediated the relationship between sCD14 and fatigue. HIV-serostatus was then tested as a moderator. Compared to HIV-negative, HIV + women had higher levels of sCD14, <i>t</i>(34) = -3.85, <i>p</i> &lt;.001, and lower thalamic degree centrality, <i>t</i>(33) = 2.17, <i>p</i> =.038. SCD14 predicted lower thalamic DC, <i>b</i> = -1.16, <i>p</i> =.035. Degree centrality predicted fatigue, <i>b</i> = -4.50, <i>p</i> =.03. Indirect and moderation effects were not significant. Monocyte activation is feature of chronic HIV-infection that impacts the number of thalamic connections to whole brain. The reduced thalamic degree centrality is associated with greater neurobiological vulnerability for fatigue after menopause.</p>

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Fatigue, monocyte activation, and degree centrality of the thalamus in post-menopausal women living with HIV

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月16日

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  • Kaitlyn Dillon,
  • Judith Lobo,
  • Suresh Pallikkuth,
  • Bonnie Levin,
  • Roger McIntosh

摘要

Post-menopause is associated with chronic fatigue, inflammation, and aberrant brain connectivity, however there is a dearth of studies comparing these effects as a function of HIV. The current study investigated whether degree centrality of the thalamus mediates the effect of sCD14, a marker of monocyte activation, on fatigue and whether those parameters vary as a function of HIV-status. Resting-state functional connectivity MRI data, blood plasma, and self-report data were collected from 16 HIV + and 25 HIV- post-menopausal women. Analyses tested whether degree centrality of the thalamus, caudate, and right putamen mediated the relationship between sCD14 and fatigue. HIV-serostatus was then tested as a moderator. Compared to HIV-negative, HIV + women had higher levels of sCD14, t(34) = -3.85, p <.001, and lower thalamic degree centrality, t(33) = 2.17, p =.038. SCD14 predicted lower thalamic DC, b = -1.16, p =.035. Degree centrality predicted fatigue, b = -4.50, p =.03. Indirect and moderation effects were not significant. Monocyte activation is feature of chronic HIV-infection that impacts the number of thalamic connections to whole brain. The reduced thalamic degree centrality is associated with greater neurobiological vulnerability for fatigue after menopause.