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<p>United States Special Operations Forces (SOF) experience neurobehavioral symptoms that can adversely affect training and combat operations. Understanding the neurobiological basis for these symptoms may guide prevention and treatment. In 29 male active-duty SOF with mean (SD) 17(4) years of service, we tested whether self-reported symptoms of apathy, disinhibition, and executive dysfunction measured by the Frontal Systems Behavior Scale, were related to functional magnetic resonance imaging and positron emission tomography biomarkers (translocator protein and tau) of the limbic, salience, and executive control networks. Higher disinhibition was associated with lower functional connectivity and higher tau signal within the salience network, though both associations diminished with age. These findings provide the basis for future multimodal studies to elucidate the relationship between neurobehavioral symptoms and neuroimaging biomarkers in the context of repeated blast exposure.</p>

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Investigating the neural network correlates of apathy, disinhibition, and executive dysfunction in active-duty United States Special Operations Forces

  • 期刊论文

  • 发表日期：

    2025年3月18日

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  • Natalie Gilmore,
  • Isabella R. McKinney,
  • Chieh-En J. Tseng,
  • Douglas N. Greve,
  • Chiara Maffei,
  • Brian C. Healy,
  • Nicole R. Zürcher,
  • Jacob M. Hooker,
  • Samantha L. Tromly,
  • Daniel P. Perl,
  • Kristen Dams-O’Connor,
  • Christine L. Mac Donald,
  • Brian L. Edlow,
  • Yelena G. Bodien

摘要

United States Special Operations Forces (SOF) experience neurobehavioral symptoms that can adversely affect training and combat operations. Understanding the neurobiological basis for these symptoms may guide prevention and treatment. In 29 male active-duty SOF with mean (SD) 17(4) years of service, we tested whether self-reported symptoms of apathy, disinhibition, and executive dysfunction measured by the Frontal Systems Behavior Scale, were related to functional magnetic resonance imaging and positron emission tomography biomarkers (translocator protein and tau) of the limbic, salience, and executive control networks. Higher disinhibition was associated with lower functional connectivity and higher tau signal within the salience network, though both associations diminished with age. These findings provide the basis for future multimodal studies to elucidate the relationship between neurobehavioral symptoms and neuroimaging biomarkers in the context of repeated blast exposure.