<p>The construction and development of multifunctional coatings on metallic orthopedic implants is a critical approach of averting the complications of implant-related infections, inflammatory reactions and poor osseointegration. In this paper, a new type of nanocomposite coating using calcium phosphate (CaP), polypropylene imine (PPI) dendrimers and silver nanoparticles (AgNPs) was effectively prepared on a metallic surface. The composite architecture is a synergistic integration of CaP, which is osteoconductive, PPI dendrimers, which have drug delivery potential, and AgNPs, which have a broad-spectrum antibacterial effect, which produces a multidimensional therapeutic effect. The product nanocomposite had controlled and sustained drug release and significantly reduced cytotoxicity but retained long bioactivity. PPI dendrimers allowed easy drug encapsulation and controlled the release kinetics, but AgNPs endowed strong antibacterial properties, thus reducing the risk of implant-associated infections. Further, CaP matrix enhanced cellular reactions—that is adhesion and proliferation of cells—therewith improving biocompatibility and accelerating bone tissue incorporation. The coating was fabricated using a scalable cost-effective, low-temperature deposition process that provided uniform coating of the surface and precise control of the thickness of the material. These information processing strengths make the methodology highly appropriate to get translated into useful biomedical applications. Overall, the signed CaP-PPI-Ag nanocomposite coating is quite promising as a new generation surface modification approach to orthopedic implants, which integrates antibacterial, anti-inflammatory and osteogenic properties.</p>