<p>This study examines the mechanical and structural properties of CuCrZr after 150&#xa0;keV Ar²⁺ irradiation at fluences ranging from 1 × 10¹⁴ to 3 × 10¹⁶ ions/cm. The irradiated and pristine specimens were systematically characterized for morphological, microstructural, and mechanical changes using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), x-ray diffraction (XRD), and nanoindentation. Scherrer analysis indicated that the crystallite size increased with fluence up to 1 × 10¹⁶ ions/cm², followed by a slight reduction at 3 × 10¹⁶ ions/cm². Williamson–Hall analysis revealed a corresponding decrease in micro-strain up to 1 × 10¹⁶ ions/cm², with a subsequent increase at the highest fluence, consistent with peak splitting observed in XRD and suggesting fluence-dependent lattice modification and possible chromium precipitation. Nanoindentation results showed enhanced hardness and modulus in the irradiated surface layer, with increasing H/E and H³/E² ratios reflecting enhanced elastic strain accommodation and resistance to plastic deformation. A reduction in the plastic-to-elastic energy ratio indicated greater elastic recovery in the irradiated region. Overall, the findings establish a clear process–structure–property correlation linking irradiation-induced effects to mechanical strengthening in CuCrZr.</p>