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<p>SiZnOC gels were coated on C/C substrate by sol–gel, using methyltriethoxysilane (CH<sub>3</sub>Si(OCH<sub>2</sub>CH<sub>3</sub>)<sub>3</sub>, MTES) and dimethyldiethoxysilane ((CH<sub>3</sub>)<sub>2</sub>Si(OCH<sub>2</sub>CH<sub>3</sub>)<sub>2</sub>, DMDES) as precursors, and zinc acetylacetonate (Zn(acac)<sub>2</sub>) as the modifier. After pyrolysis under argon at 700 °C, SiZnOC ceramics were obtained. Microstructures of SiZnOC with different Zn/Si molar ratios were characterized by FTIR, XRD, SEM and XPS. Biocompatibilities of SiZnOC ceramics were measured by MTT, cell adhesion, antimicrobial activity of Escherichia coli and Staphylococcus aureus, DPPH free radical scavenging and reactive oxygen species (ROS) levels. Vitro bioactivities of materials were evaluated by the generation of bone-like hydroxyapatite (HA) in simulated body fluid (SBF). Results showed that antibacterial and antioxidant properties of SiZnOC enhanced with the content of Zn doping. When Zn:Si molar ratio of SiZnOC increased to 0.4, the inhibition zone diameters were the biggest of 6.7&#xa0;mm and 5.4&#xa0;mm for E. coli and S. aureus, respectively, and the scavenging rate was the highest of 88.9% for the DPPH free radicals. However, the level of intracellular reactive oxygen species (ROS) expression was promoted with the increase of Zn doping either. SiOC with Zn:Si molar ratio of 0.2 has the quickest speed of generation bone-like hydroxyapatite (HA) in SBF, on the balance of biocompatibility, bioactivity and antimicrobial performance, SiZnOC with Zn:Si molar ratio of 0.2 was the best for the moderate antimicrobial and antioxidant properties, and the qualified biocompatibility.</p>

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Biocompatibility and Bioactivity of Zn-Modified SiOC Ceramic Coating on C/C Composite Substrate

  • 期刊论文

  • 发表日期：

    2026年3月30日

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  • Qidong Liu,
  • Xiumei Wu,
  • Yukang Peng,
  • Yunping Li,
  • Shu Yu,
  • Zian Xiao

摘要

SiZnOC gels were coated on C/C substrate by sol–gel, using methyltriethoxysilane (CH3Si(OCH2CH3)3, MTES) and dimethyldiethoxysilane ((CH3)2Si(OCH2CH3)2, DMDES) as precursors, and zinc acetylacetonate (Zn(acac)2) as the modifier. After pyrolysis under argon at 700 °C, SiZnOC ceramics were obtained. Microstructures of SiZnOC with different Zn/Si molar ratios were characterized by FTIR, XRD, SEM and XPS. Biocompatibilities of SiZnOC ceramics were measured by MTT, cell adhesion, antimicrobial activity of Escherichia coli and Staphylococcus aureus, DPPH free radical scavenging and reactive oxygen species (ROS) levels. Vitro bioactivities of materials were evaluated by the generation of bone-like hydroxyapatite (HA) in simulated body fluid (SBF). Results showed that antibacterial and antioxidant properties of SiZnOC enhanced with the content of Zn doping. When Zn:Si molar ratio of SiZnOC increased to 0.4, the inhibition zone diameters were the biggest of 6.7 mm and 5.4 mm for E. coli and S. aureus, respectively, and the scavenging rate was the highest of 88.9% for the DPPH free radicals. However, the level of intracellular reactive oxygen species (ROS) expression was promoted with the increase of Zn doping either. SiOC with Zn:Si molar ratio of 0.2 has the quickest speed of generation bone-like hydroxyapatite (HA) in SBF, on the balance of biocompatibility, bioactivity and antimicrobial performance, SiZnOC with Zn:Si molar ratio of 0.2 was the best for the moderate antimicrobial and antioxidant properties, and the qualified biocompatibility.