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<p>Barrier membrane plays a crucial role in periodontal assisted accelerated osteogenic orthodontics (PAOO), where they prevent soft tissue infiltration and provide a protected space for bone regeneration. Biodegradable Zn-Cu alloys have shown promising potential for such applications. In this preliminary study, the effects of Cu content on the degradation resistance, stress corrosion behavior, and cytocompatibility of as-rolled Zn-xCu alloys intended for PAOO barrier membranes were systematically investigated. The results revealed that with increasing Cu content, the corrosion resistance of the alloys decreased. Mechanically, the ultimate tensile strength (UTS) generally increased with Cu addition. Under stress corrosion conditions, the Zn-1Cu alloy demonstrated the highest fracture elongation (17%). In terms of biological performance, a Cu content of 1 wt.% resulted in a 100% antibacterial rate against&#xa0;<i>Escherichia coli</i>. Furthermore, the Zn-1Cu alloy exhibited the best cytocompatibility. The as-rolled Zn-1Cu alloy shows great potential as a barrier membrane material for PAOO applications.</p>

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A Preliminary Investigation into the Effects of Cu Content on Degradation Resistance, Stress Corrosion, and Cytocompatibility of Zn-xCu Alloys as PAOO Barrier Membranes

  • 期刊论文

  • 发表日期：

    2026年5月23日

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  • Siyuan Liao,
  • Xiaojun Zhou,
  • Sharafadeen Kunle Kolawole,
  • Muhammad Ali Siddiqui,
  • Junxiu Chen,
  • Zhongjian Chen,
  • Xiangbing Wu,
  • Zhiyun Song

摘要

Barrier membrane plays a crucial role in periodontal assisted accelerated osteogenic orthodontics (PAOO), where they prevent soft tissue infiltration and provide a protected space for bone regeneration. Biodegradable Zn-Cu alloys have shown promising potential for such applications. In this preliminary study, the effects of Cu content on the degradation resistance, stress corrosion behavior, and cytocompatibility of as-rolled Zn-xCu alloys intended for PAOO barrier membranes were systematically investigated. The results revealed that with increasing Cu content, the corrosion resistance of the alloys decreased. Mechanically, the ultimate tensile strength (UTS) generally increased with Cu addition. Under stress corrosion conditions, the Zn-1Cu alloy demonstrated the highest fracture elongation (17%). In terms of biological performance, a Cu content of 1 wt.% resulted in a 100% antibacterial rate against Escherichia coli. Furthermore, the Zn-1Cu alloy exhibited the best cytocompatibility. The as-rolled Zn-1Cu alloy shows great potential as a barrier membrane material for PAOO applications.