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<p>Biodegradable Zn alloys have good mechanical strength and biodegradability, which can effectively solve clinical problems such as stress shielding and reoperation. In this study, we propose a novel biodegradable Zn-0.5&#xa0;Mg alloy bone plate and establish corrosion models considering the degradation of the plates when they are used for fracture. FEA is used to investigate the mechanical behavior of the Zn-0.5&#xa0;Mg alloy bone plate in vitro under physiological loading conditions. Moreover, a comparative analysis of the biomechanical performance between Zn-0.5&#xa0;Mg alloy and Titanium (Ti) alloy bone plate is also evaluated in a tibia fracture model of rabbit. The three-point bending test is employed to validate the maximum fracture force and flexural strength of the fixed fracture bone. The results indicate that the designed Zn-0.5&#xa0;Mg alloy bone plate model is safe when being used as a fixation plate. The stress shielding rate of Zn-0.5&#xa0;Mg alloy bone plate decreases by 30.38% three months after implantation. In addition, the flexural strength of the fracture tibia fixed with Zn-0.5&#xa0;Mg alloy group is similar to Ti alloy bone plate group 3&#xa0;months after surgery. The biodegradable Zn-0.5&#xa0;Mg alloy bone plate could effectively fix the tibia fracture of rabbit with lower stress shielding rate compared to the Ti alloy bone plate. It can be concluded that the Zn-0.5&#xa0;Mg alloy bone plate has promising application in the field of orthopaedical implants.</p>

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Finite Element Analysis of Zn-0.5 Mg Alloy Bone Plates over Tibia Fracture Model in Rabbit

  • 期刊论文

  • 发表日期：

    2026年1月13日

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  • Tianwei Zhang,
  • Jing Wang,
  • Xin Geng,
  • Fuyang Wang,
  • Xingyuan Han,
  • Xing Yang,
  • Weidan Wang,
  • Bingchen Zhu,
  • Liangliang Cheng,
  • Hang Li,
  • Ronghua Li,
  • Dewei Zhao

摘要

Biodegradable Zn alloys have good mechanical strength and biodegradability, which can effectively solve clinical problems such as stress shielding and reoperation. In this study, we propose a novel biodegradable Zn-0.5 Mg alloy bone plate and establish corrosion models considering the degradation of the plates when they are used for fracture. FEA is used to investigate the mechanical behavior of the Zn-0.5 Mg alloy bone plate in vitro under physiological loading conditions. Moreover, a comparative analysis of the biomechanical performance between Zn-0.5 Mg alloy and Titanium (Ti) alloy bone plate is also evaluated in a tibia fracture model of rabbit. The three-point bending test is employed to validate the maximum fracture force and flexural strength of the fixed fracture bone. The results indicate that the designed Zn-0.5 Mg alloy bone plate model is safe when being used as a fixation plate. The stress shielding rate of Zn-0.5 Mg alloy bone plate decreases by 30.38% three months after implantation. In addition, the flexural strength of the fracture tibia fixed with Zn-0.5 Mg alloy group is similar to Ti alloy bone plate group 3 months after surgery. The biodegradable Zn-0.5 Mg alloy bone plate could effectively fix the tibia fracture of rabbit with lower stress shielding rate compared to the Ti alloy bone plate. It can be concluded that the Zn-0.5 Mg alloy bone plate has promising application in the field of orthopaedical implants.