<p>Pure titanium and titanium alloys have been used extensively in orthopedics, orthopedic surgery, and oral clinical practice because of their excellent mechanical properties and biocompatibility. However, complications such as loosening, sinking, and infection develop gradually after titanium implants are implanted, increasing the degree of difficulty for clinicians. In this study, a manganese-doped titanium dioxide coating was prepared on the surface of titanium through microarc oxidation technology. The surface properties of the manganese-doped titanium dioxide coating were evaluated by scanning electron microscopy, energy-dispersive spectrometry, X-ray diffraction (XRD), and profilometry, with an emphasis on the corrosion resistance and wear resistance of the coating. On this basis, osteoblasts were planted on the surface of the coating, and the cytocompatibility and cell activity of the manganese-doped titanium dioxide coating on osteoblasts were evaluated by methods such as the staining of live and dead cells. The experimental results indicated that a manganese-doped titanium dioxide coating was successfully prepared on the titanium surface. The doping of manganese increased the roughness and hydrophilicity of the titanium. More importantly, the corrosion resistance and wear resistance of the coating were excellent. Furthermore, osteoblasts grow well on the surface of the manganese-doped titanium dioxide coating, which can promote their adhesion and proliferation. Preparing manganese-doped titanium dioxide coatings on the surface of titanium via microarc oxidation is feasible, providing a new concept for the early healing of titanium implants and the repair of bone defects.</p>