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<p>Bioactive glasses and glass-ceramics exhibit considerable potential in the treatment of tumors via hyperthermia. This research focused on synthesizing a nickel oxide (NiO) borate-doped bioactive glass with the composition of 45-x B<sub>2</sub>O<sub>3</sub>, 24.5 CaO, 24.5 Na<sub>2</sub>O, and 6 P<sub>2</sub>O<sub>5</sub>, where x = 0, 0.2, 0.5, or 1&#xa0;wt.% NiO. The process involved melt quenching, followed by a controlled crystallization to produce a glass-ceramic structure. Bioactivity was evaluated by immersion in simulated body fluid (SBF) for two and four weeks. Characterization techniques, including x-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and vibrating sample magnetometry (VSM), revealed the structural transformation from amorphous to crystalline phases and confirmed the formation of hydroxyapatite (HA) after immersion. Additionally, the calculated change in N4's value indicates the conversion of the structural units BO3 and BO4, which form HA. Scanning electron microscopy (SEM) revealed a morphological change in the cotton-like apatite structures. The significant increase in tetracoordinated boron (N<sub>4</sub>) after one week of immersion further confirmed the bioactivity. Differential thermal analysis (DTA) demonstrated improved thermal stability and glass transition temperature with nickel oxide, while vibrating sample magnetization (VSM) measurements confirmed improved magnetic properties. Optical properties evaluated using UV/visible spectroscopy confirmed these results, revealing distinct absorption peaks associated with electronic transitions in the hyaluronic acid structure. The results indicated that the addition of NiO enhances magnetic properties and facilitates the controlled release of therapeutic agents, making these materials promising candidates for targeted cancer therapies.</p>

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Nickel-Oxide-Doped Borate Hench Glass for Magnetic Hyperthermia Applications

  • 期刊论文

  • 发表日期：

    2025年12月29日

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  • A. El-gendy,
  • Nahla.M. Salatein,
  • Irene S. Fahim,
  • A. M. Abdelghany,
  • Y. Abdou,
  • F. A. El Hussiny,
  • B. M. Elmowafy

摘要

Bioactive glasses and glass-ceramics exhibit considerable potential in the treatment of tumors via hyperthermia. This research focused on synthesizing a nickel oxide (NiO) borate-doped bioactive glass with the composition of 45-x B2O3, 24.5 CaO, 24.5 Na2O, and 6 P2O5, where x = 0, 0.2, 0.5, or 1 wt.% NiO. The process involved melt quenching, followed by a controlled crystallization to produce a glass-ceramic structure. Bioactivity was evaluated by immersion in simulated body fluid (SBF) for two and four weeks. Characterization techniques, including x-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and vibrating sample magnetometry (VSM), revealed the structural transformation from amorphous to crystalline phases and confirmed the formation of hydroxyapatite (HA) after immersion. Additionally, the calculated change in N4's value indicates the conversion of the structural units BO3 and BO4, which form HA. Scanning electron microscopy (SEM) revealed a morphological change in the cotton-like apatite structures. The significant increase in tetracoordinated boron (N4) after one week of immersion further confirmed the bioactivity. Differential thermal analysis (DTA) demonstrated improved thermal stability and glass transition temperature with nickel oxide, while vibrating sample magnetization (VSM) measurements confirmed improved magnetic properties. Optical properties evaluated using UV/visible spectroscopy confirmed these results, revealing distinct absorption peaks associated with electronic transitions in the hyaluronic acid structure. The results indicated that the addition of NiO enhances magnetic properties and facilitates the controlled release of therapeutic agents, making these materials promising candidates for targeted cancer therapies.