<p>Simple pressure vessels by deep drawing are widely used in medical, petrochemical, packaging, electronic power, and other fields because of simple structure, non-toxic medium, no pollution to the environment, and low cost. Residual stresses are induced during the deep drawing of the material, which affects the quality of dished end formed and produces defects such as crack or abnormal deformation. In this paper, the process parameters of deep drawing process are optimized, and the finite element software ABAQUS is used to model. The magnitude of residual stress in forming process and induced the distribution before and after cutting edge are discussed. Box–Benhnken design (BBD) response surface method is used to study the influence of parameters, such as blank-holder force, friction coefficient, and corner radius of the die, the maximum residual stress in the area of deep drawing dished end away from the cut gap is obtained, and the optimal combination of structural parameters is evaluated. The residual stress in dished ends by deep drawing is tested by blind-hole-drilling method. The reliability of the finite element model is validated by comparing the test results and numerical results.</p>