<p>Artificial saliva and fluorinated artificial saliva were investigated explicitly for corrosion on additively manufactured Ti6Al4V. A study was conducted to evaluate the corrosion resistance of three specimens: as-built (AM), annealed at 930&#xa0;°C, and 1050&#xa0;°C. Larger grains of the specimen treated at 1050&#xa0;°C positively influenced the corrosion resistance. The decline in passivation stability was observed in as-built specimens and annealed specimens at 930&#xa0;°C. Fluorinated saliva shows significantly higher corrosion (about nine times) than the as-built condition, whereas specimens treated at 1050&#xa0;°C demonstrate superior corrosion resistance across all electrolytes. The specimens treated at 1050&#xa0;°C consistently indicate an upward shift in <i>E</i>_corr values, suggesting progressive corrosion resistance. The relationship between corrosion current density (<i>i</i>_corr) and grain characteristics was established. High-angle and low-angle grain boundaries displayed positive correlations with the corrosion current density. The specimens annealed at 1050&#xa0;°C demonstrated significantly improved corrosion resistance in different electrolytes, suggesting heat treatment could enhance the alloy’s performance and suitability for biomedical and dental prosthetic applications.</p> Graphical Abstract <p></p>