<p>A novel praseodymium oxide (Pr₆O₁₁)-doped germanate glass series was fabricated with a chemical composition of 20TeO₂-<i>x</i>Pr₆O₁₁-10GeO₂-35MgO-(35-<i>x</i>)B₂O₃; <i>x</i> = 1.25, 2.5, and 3.75 mol.%. The structural, optical, mechanical, and radiation-protective properties of fabricated glasses were evaluated in relation to the partial substitution of Pr₆O₁₁ for B₂O₃. The glass structure was studied using XRD analysis to better understand the glass system that includes nano-praseodymium (Pr). Archimedes’ method was employed to ascertain the density of praseodymium (Pr)-doped glass. Additionally, the Makishima and Mackenzie model explained how the mechanical properties changed as more praseodymium (Pr) was added to the glass. The germanate glass made with 3.75 mol.% of Pr₆O₁₁ showed the highest linear attenuation coefficient compared to the other fabricated glasses, according to the Monte Carlo simulation. As the γ-ray energy increased from 0.015 to 15 MeV, the linear attenuation coefficient fluctuated between 147.388 and 0.126 cm⁻¹. Concurrently, it exhibits a thinner half-value thickness, which fluctuates between 0.005 and 5.516 cm as the photon energy increases from 0.015 to 15 MeV. The lead equivalent thickness of the germanate glass gets smaller, and its ability to protect against radiation gets better because of the increase in the linear attenuation coefficient of the glass with 3.75 mol.% Pr₆O₁₁ at the selected energy intervals.</p>