<p>Developing high-performance structural metallic materials with an optimal balance of strength and plasticity has been a long-standing goal for materials scientists. In this study, the Ni₅₀Co₂₄Fe₁₉Ti₄Al₃ (at.%) MPEA was successfully fabricated using vacuum arc-melting technology, followed by a series of mechanical and thermal treatments. The results indicate that the alloy consists of equiaxed grains with an average grain size of approximately 100 μm and precipitates a cubic L1₂ phase with a volume fraction of about 29%, which maintains a coherent relationship with the FCC matrix. Tensile property tests reveal that the alloy exhibits a yield strength of ~ 850 MPa while maintaining a fracture &#xa0;strain of 22.5%, demonstrating an excellent strength–ductility balance. Furthermore, calculations of strength contributions show that precipitation strengthening is the primary strengthening mechanism. This study demonstrates that the precipitation of coherent secondary phases in an FCC matrix can enable the alloy to achieve both high strength and good fracture plasticity. The findings provide a design strategy and experimental foundation for the development of high-performance alloys with an optimal balance of strength and ductility.</p>