<p>In the field of dentistry, the process of resorption and atrophy of the alveolar bone is frequently observed foll,owing tooth extraction, a phenomenon that can significantly impact the recovery process of patients undergoing dental implant treatment. Bone powder has emerged as a promising solution for the reconstruction of alveolar bone, offering a protective barrier and a means to replenish defective bone tissue by filling the voids with this material. Hydroxyapatite (HA) bone powder has garnered significant attention in research endeavors focused on bone restoration materials, owing to its distinctive advantages. In this study, a novel approach was employed, utilizing yeast as a template for synthesizing HA bone powder with a high specific surface area and mesoporous structure. The performance and formation mechanism of HA bone powder were thoroughly investigated, with the objective of providing a more effective solution for bone repair. The experimental findings demonstrated that the particle characteristics of HA precursors with varying fermentation times exhibited variability, and the sintering temperature influenced the crystallinity, particle size, and pore structure of porous HA. The most optimal samples were identified through a comparative analysis with Bio-Oss bone powders. The rate of change in mineralization quality and the rate of release of degraded calcium and phosphorus ions exhibited variation in accordance with different fermentation times. The binding mode and energy difference between phenylalanine and Ca²⁺ were revealed by density flooding theory and provided heterogeneous nucleation sites for HA nucleation, which ultimately led to the formation of a porous structure. However, the study is not without its limitations, and the process can be further optimized in the future to explore the long-term performance and biocompatibility of the material in vivo. This would expand the scope of application and provide better solutions for dental and alveolar bone problems.</p>