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<p>The primary objective of this study is to evaluate the biodegradability of polylactic acid-based scaffolds in phosphate buffer solution. Applying 3D printing technology via fused deposition modeling, 27 porous scaffolds were fabricated. The weight loss and pH values of the 27 scaffolds immersed in phosphate buffer solution remained neutral throughout the incubation period until the sixth week, when they began to fall significantly. The maximum swelling of 7.04% was observed in the scaffold with a layer thickness of 0.20&#xa0;mm, a scanning speed of 30&#xa0;mm/sec, and 60% of infill. Furthermore, surface modification of scaffolds was done by virtue of gold-palladium sputter coating, which was an attemptable approach for the development of gold-palladium coated polylactic acid scaffolds for the first time. The electrochemical analysis allowed us to observe that the coated scaffolds followed pseudo-passivation owing to their physical gold-palladium coating characteristics (electropositive nature), prompting an improvement in the formation of the gold-palladium adsorbed and electrolytic solution absorbed (adsorption–absorption)-based layer on scaffolds.</p>

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Evaluation of In Vitro and Electrochemical Degradation of Additively Manufactured Polymeric Scaffolds

  • 期刊论文

  • 发表日期：

    2025年5月19日

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  • Siddhant Gade,
  • Sunita Yadav,
  • Shashikant Vagge,
  • Raju Panchal

摘要

The primary objective of this study is to evaluate the biodegradability of polylactic acid-based scaffolds in phosphate buffer solution. Applying 3D printing technology via fused deposition modeling, 27 porous scaffolds were fabricated. The weight loss and pH values of the 27 scaffolds immersed in phosphate buffer solution remained neutral throughout the incubation period until the sixth week, when they began to fall significantly. The maximum swelling of 7.04% was observed in the scaffold with a layer thickness of 0.20 mm, a scanning speed of 30 mm/sec, and 60% of infill. Furthermore, surface modification of scaffolds was done by virtue of gold-palladium sputter coating, which was an attemptable approach for the development of gold-palladium coated polylactic acid scaffolds for the first time. The electrochemical analysis allowed us to observe that the coated scaffolds followed pseudo-passivation owing to their physical gold-palladium coating characteristics (electropositive nature), prompting an improvement in the formation of the gold-palladium adsorbed and electrolytic solution absorbed (adsorption–absorption)-based layer on scaffolds.