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<p>Development of nonenzymatic glucose sensors with low cost and biocompatibility is a real challenge. This study reports the development of an ecofriendly nonenzymatic glucose sensor by incorporating tin dioxide (SnO<sub>2</sub>) nanoparticles onto graphite electrodes (GEs). The crystal structure, morphology, elemental composition, and chemical bonds of the prepared SnO<sub>2</sub> nanoparticles were characterized by x-ray diffractometry (XRD) and field-emission scanning electron microscopy (FESEM) along with energy-dispersive spectroscopy (EDX) and Fourier-transform infrared (FTIR) spectroscopy. The electrochemical properties of the prepared nanoparticles were examined by cyclic voltammetry, differential pulse voltammetry, chronoamperometry, and electrochemical impedance spectroscopy. The SnO<sub>2</sub> nanoparticles had plate-like structures interweaved with highly porous nanoparticles. Electrochemical characterization revealed that SnO<sub>2</sub>/GE exhibited high sensitivity, a low detection limit (LOD) of 0.029&#xa0;mM and 0.82&#xa0;mM, and a quantification limit (LOQ) of 0.0897&#xa0;mM and 2.48&#xa0;mM within a linear range of 0.005–0.1&#xa0;mM and 1–7.5&#xa0;mM. The SnO<sub>2</sub>/GE exhibited a very low relative standard deviation (RSD, &lt; 10%) and retained stability after 100 continuous cycles at alkaline pH. The sensing performance of the material was demonstrated with different pH values and temperatures in the range of 30–50°C, resulting in an increase of current with a <i>R</i><sup>2</sup> value of 0.9533 and 0.989. Real-time urine analysis was carried out, and a recovery percentage &gt; 80% was obtained. These findings demonstrate that SnO<sub>2</sub>/GE is a potential electrode for nonenzymatic glucose sensing applications.</p> Graphical Abstract <p></p>

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Facile Development of a SnO2-Based Nonenzymatic Glucose Sensor with Enhanced Electrochemical Response

  • 期刊论文

  • 发表日期：

    2025年12月4日

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  • P. R. Arya,
  • S. Radha,
  • B. S. Sreeja,
  • K. K. Mythili

摘要

Development of nonenzymatic glucose sensors with low cost and biocompatibility is a real challenge. This study reports the development of an ecofriendly nonenzymatic glucose sensor by incorporating tin dioxide (SnO2) nanoparticles onto graphite electrodes (GEs). The crystal structure, morphology, elemental composition, and chemical bonds of the prepared SnO2 nanoparticles were characterized by x-ray diffractometry (XRD) and field-emission scanning electron microscopy (FESEM) along with energy-dispersive spectroscopy (EDX) and Fourier-transform infrared (FTIR) spectroscopy. The electrochemical properties of the prepared nanoparticles were examined by cyclic voltammetry, differential pulse voltammetry, chronoamperometry, and electrochemical impedance spectroscopy. The SnO2 nanoparticles had plate-like structures interweaved with highly porous nanoparticles. Electrochemical characterization revealed that SnO2/GE exhibited high sensitivity, a low detection limit (LOD) of 0.029 mM and 0.82 mM, and a quantification limit (LOQ) of 0.0897 mM and 2.48 mM within a linear range of 0.005–0.1 mM and 1–7.5 mM. The SnO2/GE exhibited a very low relative standard deviation (RSD, < 10%) and retained stability after 100 continuous cycles at alkaline pH. The sensing performance of the material was demonstrated with different pH values and temperatures in the range of 30–50°C, resulting in an increase of current with a R2 value of 0.9533 and 0.989. Real-time urine analysis was carried out, and a recovery percentage > 80% was obtained. These findings demonstrate that SnO2/GE is a potential electrode for nonenzymatic glucose sensing applications.

Graphical Abstract