Scholarlink

<p>Early and accurate detection of cancer remains a global medical challenge, as conventional diagnostic tools such as magnetic resonance imaging (MRI), computed tomography (CT), and histopathology often suffer from limited sensitivity and specificity. Recent studies have identified extracellular vesicles (EVs), particularly exosomes, as reliable biomarkers for early cancer diagnosis due to their critical role in tumor progression. In this study, we present an ultrasensitive nanophotonic terahertz biosensor designed for the noninvasive detection of cancer-related exosomes. The proposed device integrates heterogeneous metal resonators composed of nickel (Ni) and silver (Ag), separated by a silicon dioxide (SiO<sub>2</sub>) dielectric layer, forming a compact three-layer architecture with overall dimensions of 100 × 100 nm<sup>2</sup> and a thickness of 20 nm. Full-wave electromagnetic simulations were performed to analyze its optical response, including absorption spectra, electric and magnetic field distributions, and surface current behavior. The biosensor achieves perfect absorption exceeding 99% across the 0–30 THz range, exhibiting remarkable angular stability and polarization insensitivity. Comparative analysis demonstrates that the proposed structure outperforms existing terahertz biosensors in terms of bandwidth and absorption uniformity. Furthermore, the sensor effectively differentiates between normal and cancerous exosomes by detecting variations in dielectric properties associated with differences in protein composition and morphology. These results confirm the biosensor’s potential as a compact, label-free, and highly efficient platform for terahertz-based noninvasive early cancer diagnostics.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Terahertz Nanophotonic Hybrid-Metal Biosensor for Ultrasensitive, Noninvasive Cancer Detection Via Exosome Biomarkers

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月12日

查看全文
  • Musa N. Hamza,
  • Mohammad Tariqul Islam,
  • Sunil Lavadiya,
  • Iftikhar ud Din,
  • Bruno Sanches,
  • Slawomir Koziel,
  • Syeda Iffat Naqvi,
  • Abinash Panda,
  • Md. Shabiul Islam

摘要

Early and accurate detection of cancer remains a global medical challenge, as conventional diagnostic tools such as magnetic resonance imaging (MRI), computed tomography (CT), and histopathology often suffer from limited sensitivity and specificity. Recent studies have identified extracellular vesicles (EVs), particularly exosomes, as reliable biomarkers for early cancer diagnosis due to their critical role in tumor progression. In this study, we present an ultrasensitive nanophotonic terahertz biosensor designed for the noninvasive detection of cancer-related exosomes. The proposed device integrates heterogeneous metal resonators composed of nickel (Ni) and silver (Ag), separated by a silicon dioxide (SiO2) dielectric layer, forming a compact three-layer architecture with overall dimensions of 100 × 100 nm2 and a thickness of 20 nm. Full-wave electromagnetic simulations were performed to analyze its optical response, including absorption spectra, electric and magnetic field distributions, and surface current behavior. The biosensor achieves perfect absorption exceeding 99% across the 0–30 THz range, exhibiting remarkable angular stability and polarization insensitivity. Comparative analysis demonstrates that the proposed structure outperforms existing terahertz biosensors in terms of bandwidth and absorption uniformity. Furthermore, the sensor effectively differentiates between normal and cancerous exosomes by detecting variations in dielectric properties associated with differences in protein composition and morphology. These results confirm the biosensor’s potential as a compact, label-free, and highly efficient platform for terahertz-based noninvasive early cancer diagnostics.