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<p>In this work, a novel modified graphene paste electrode (P(L-TY)/MGPE) was developed through polymerization of L-tyrosine (L-TY) and was used for electrochemical detection of melatonin (MLT). Its oxidation peak was observed at 0.349&#xa0;V, with the corresponding current response of 8.46 µA in 0.2&#xa0;M phosphate-buffered saline (PBS) solution at pH 1.0. Scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV) were employed to study the electrochemical behavior of the P(L-TY)/MGPE and bare graphene paste electrode (BGPE). The sensor demonstrated strong resistance to interference from various metal ions and organic molecules. A scan rate study suggested that the oxidation process followed an adsorption-based mechanism. The effects of pH and concentration were also investigated. The modified electrode achieved a detection limit of 0.5 × 10<sup>−6</sup>&#xa0;M and a quantification limit of 1.6 × 10<sup>−6</sup>&#xa0;M. Additionally, P(L-TY)/MGPE demonstrated excellent stability, reproducibility, and repeatability. The sensor was successfully applied for analysis of a real sample of pharmaceutical tablets, confirming its reliability for melatonin detection in commercial formulations.</p> Graphical Abstract <p></p>

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Analysis of Melatonin Using a Poly(L-Tyrosine)-Modified Graphene Paste Electrode

  • 期刊论文

  • 发表日期：

    2025年6月19日

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  • D. Sumanth,
  • J. G. Manjunatha,
  • T. M. Almutairi,
  • N. Ataollahi

摘要

In this work, a novel modified graphene paste electrode (P(L-TY)/MGPE) was developed through polymerization of L-tyrosine (L-TY) and was used for electrochemical detection of melatonin (MLT). Its oxidation peak was observed at 0.349 V, with the corresponding current response of 8.46 µA in 0.2 M phosphate-buffered saline (PBS) solution at pH 1.0. Scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV) were employed to study the electrochemical behavior of the P(L-TY)/MGPE and bare graphene paste electrode (BGPE). The sensor demonstrated strong resistance to interference from various metal ions and organic molecules. A scan rate study suggested that the oxidation process followed an adsorption-based mechanism. The effects of pH and concentration were also investigated. The modified electrode achieved a detection limit of 0.5 × 10−6 M and a quantification limit of 1.6 × 10−6 M. Additionally, P(L-TY)/MGPE demonstrated excellent stability, reproducibility, and repeatability. The sensor was successfully applied for analysis of a real sample of pharmaceutical tablets, confirming its reliability for melatonin detection in commercial formulations.

Graphical Abstract