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<p>The development of a selective, sensitive, and effective electrochemical sensor for the simultaneous analysis of multiple drugs presents a significant and urgent challenge. In this work, an electrochemical sensor capable of separating and detecting paracetamol (PAR) and diclofenac sodium hydrochloride (DIC) was constructed through the synthesis of a carbon nanotube (CNT)-doped hydrogel. Because of the hydrophilic functional groups on CNTs, they can be uniformly dispersed in organic precursor solution to form a homogeneous conductive hydrogel. The structure and morphology of the CNT-doped hydrogel was studied by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The operating conditions of the sensor were optimized, including the hydrogel volume, electrolyte pH, electrochemical deposition potential, and deposition time. Under optimal working conditions, the linear ranges for PAR and DIC detection were 10–80&#xa0;μM and 10–80&#xa0;μM, with detection limits of 3.5 and 3.6&#xa0;μM, respectively. In addition, the hydrogel sensor demonstrated good reproducibility, long-term stability, excellent flexibility in bending and twisting, and favorable mechanical properties, with a maximum strain rate of 478% and tensile strength of 0.102&#xa0;MPa. This research provides a new flexible material for drug separation sensors, and opens up a new research platform for hydrogels.</p>

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A Flexible Electrochemical Sensor for Simultaneous Detection of Acetaminophen and Diclofenac Sodium Using a Carbon Nanotube-Doped Hydrogel

  • 期刊论文

  • 发表日期：

    2025年6月9日

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  • Linghui Tang,
  • Yufeng Huang,
  • Yue Wang,
  • Hongbin Zhao

摘要

The development of a selective, sensitive, and effective electrochemical sensor for the simultaneous analysis of multiple drugs presents a significant and urgent challenge. In this work, an electrochemical sensor capable of separating and detecting paracetamol (PAR) and diclofenac sodium hydrochloride (DIC) was constructed through the synthesis of a carbon nanotube (CNT)-doped hydrogel. Because of the hydrophilic functional groups on CNTs, they can be uniformly dispersed in organic precursor solution to form a homogeneous conductive hydrogel. The structure and morphology of the CNT-doped hydrogel was studied by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The operating conditions of the sensor were optimized, including the hydrogel volume, electrolyte pH, electrochemical deposition potential, and deposition time. Under optimal working conditions, the linear ranges for PAR and DIC detection were 10–80 μM and 10–80 μM, with detection limits of 3.5 and 3.6 μM, respectively. In addition, the hydrogel sensor demonstrated good reproducibility, long-term stability, excellent flexibility in bending and twisting, and favorable mechanical properties, with a maximum strain rate of 478% and tensile strength of 0.102 MPa. This research provides a new flexible material for drug separation sensors, and opens up a new research platform for hydrogels.