<p>Creep deformation at high temperatures is accompanied by concurrent microstructural evolution including grain growth and cavitation, which govern the lifespan of structural components. In the present work, a coupled multi-physics modeling is developed to simulate the simultaneous evolution of grain structure and cavitation during creep of AA5052. The model integrates the probabilistic cellular automata framework coupled with finite element analysis to determine the rate of grain growth and cavitation. The stress distribution due to the presence of thermally stable hard particles was first defined through the finite element analysis. Moreover, in order to simulate the multi-timescale nature of grain boundary migration and cavity growth, a dynamic adaptive cell size methodology was introduced to incorporate both grain growth and cavitation at each time step. The experimental creep tests were also conducted at various temperatures and stresses to calibrate the model as well as to validate the simulations. The model successfully reproduced experimentally observed cavity morphologies, cavity volume fractions, and grain size evolution. A sensitivity analysis was performed to evaluate the influence of model parameters on cavity evolution and grain growth. Accordingly, this framework provides a robust predictive tool for analyzing coupled microstructural evolution and creep damage in aluminum alloys.</p>