<p>In this study, two novel non-equiatomic lightweight high-entropy alloys (LWHEAs), Al₅₀Ti₂₀Cr₁₅Mn₁₀Fe₅ and Al₅₀Ti₂₀Cr₁₅Fe₁₀Nb₅, were designed based on empirical parameters together with the CALPHAD method in order to develop an alloy with low density and high strength. Structural analyses of fabricated alloys revealed the formation of multiple phases, including body-centered cubic (BCC) and intermetallic compounds such as C14-Laves phases. Both alloys demonstrated low densities ranging between 4.23 and 4.37&#xa0;g/cm³. The mechanical properties of the alloys were evaluated in as-cast and homogenized conditions. The Al₅₀Ti₂₀Cr₁₅Fe₁₀Nb₅ and Al₅₀Ti₂₀Cr₁₅Mn₁₀Fe₅ alloys exhibited superior mechanical properties in the homogenized state with compressive fracture stress of 1587 and 1200&#xa0;MPa and microhardness of 529 and 454&#xa0;HV, respectively. The results indicate that the presence of Nb promotes the formation of stable intermetallic phases in the microstructure, which improves the strength. The properties of developed LWHEAs highlight their potential as advanced lightweight materials offering an ideal combination of low density and exceptional mechanical performance, applicable for automotive and aerospace industries in which weight reduction is in high demand.</p>