<p>Using a liquid metal cooling (LMC) directional solidification furnace combined with the seeding technique, samples of nickel-based single crystal superalloy DD6 were prepared with 〈001〉 crystal orientations deviating from the directional solidification axis by 0 to 45 deg. The study investigated the influence of growth orientation on the solidification process of nickel-based single crystal superalloys. Experimental results showed that single crystal samples with 〈001〉 orientations deviating from the directional solidification direction exhibited linear dendrite arrangements, with the development positions of tertiary dendrites capable of transforming into primary dendrites gradually migrating toward the center of the sample. As the growth orientation deviation angle increased, the asymmetry of secondary dendrites on both sides of the primary dendrites intensified. At the same time, the width of the mushy zone and the volume fraction of the γ/γ′ eutectic decreased, and the degree of microsegregation decreased. Conversely, the primary dendrite arm spacing, the volume and size of the dendritic γ′ phase, and the volume fraction of microscopic porosity all increased with an increase of growth orientation deviation angle.</p>