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Background <p>A 35-year-old man was diagnosed with tumor-induced osteomalacia (TIO) caused by a phosphaturic mesenchymal tumor (PMT) in the right maxilla.</p> Case Summary <p>The patient underwent CT-guided cryoablation at our institution, which successfully eradicated the tumor while preserving the pulpal vitality of adjacent teeth. We describe the clinical history, physical examination findings, laboratory tests, functional imaging, and follow-up protocol for evaluating treatment outcomes. Cryoablation demonstrated therapeutic efficacy through symptomatic relief, normalization of serum phosphorus levels, and maintenance of pulpal vitality, as well as preservation of neighboring natural teeth.</p> Conclusion <p>Although extensive surgical resection remains the standard treatment for PMTs in jaw bones, image-guided cryoablation presents a minimally invasive alternative. This approach offers significant advantages in preserving occlusal anatomy and functionality, marking a paradigm shift in TIO management.</p>

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Successful cryoablation for a phosphaturic mesenchymal tumor in the maxilla causing tumor-induced osteomalacia: a case report

  • 期刊论文

  • 发表日期：

    2025年4月9日

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  • Yindong Liu,
  • Mengyao Guo,
  • Xiaoding Liu,
  • Huanwen Wu,
  • Yan Jiang,
  • Zhiwei Wang,
  • Hongli Jing,
  • Weibo Xia,
  • Jizhi Zhao,
  • Lian Zhou

摘要

Background

A 35-year-old man was diagnosed with tumor-induced osteomalacia (TIO) caused by a phosphaturic mesenchymal tumor (PMT) in the right maxilla.

Case Summary

The patient underwent CT-guided cryoablation at our institution, which successfully eradicated the tumor while preserving the pulpal vitality of adjacent teeth. We describe the clinical history, physical examination findings, laboratory tests, functional imaging, and follow-up protocol for evaluating treatment outcomes. Cryoablation demonstrated therapeutic efficacy through symptomatic relief, normalization of serum phosphorus levels, and maintenance of pulpal vitality, as well as preservation of neighboring natural teeth.

Conclusion

Although extensive surgical resection remains the standard treatment for PMTs in jaw bones, image-guided cryoablation presents a minimally invasive alternative. This approach offers significant advantages in preserving occlusal anatomy and functionality, marking a paradigm shift in TIO management.