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Summary <p>Bone mineral density (BMD) reference data for the Spanish population come from the Multicenter Research Project on Osteoporosis (MRPO) in 1989. The OsteoSER study updated Spanish BMD reference data, showing similarities with MRPO and NHANES III. Peak bone mass occurred at 20–39&#xa0;years, positively associated with physical activity and negatively with smoking. Osteopenia affected 54.4%, and osteoporosis 10.7% of adults ≥ 50&#xa0;years, with higher&#xa0;prevalence in women and increasing with age.</p> Purpose <p>This study aimed to estimate the distribution of BMD in lumbar spine, femoral neck, and total hip in the Spanish population aged ≥ 20&#xa0;years and compare it with MRPO and NHANES III data.</p> Methods <p>A multicenter cross-sectional observational study was conducted in a White Spanish population aged 20–80&#xa0;years across 12 urban and rural municipalities. Participants were selected by primary care physicians based on inclusion criteria (stratified by sex, age, and BMI) and exclusion criteria (artifacts in BMD imaging in participants of all ages and conditions affecting bone density in younger participants). A vehicle with a Hologic® Horizon W densitometer traveled to each municipality.</p> Results <p>A total of 1522 participants underwent densitometry (51.8% men). Peak bone mass is reached at ages 20–39&#xa0;years in both sexes at all sites. BMD was positively associated with height, BMI, and physical activity and negatively with smoking (<i>p</i> &lt; 0.05). The distribution of BMD by age and sex was comparable to MRPO and NHANES III. We found that 54.4% of postmenopausal women and men ≥ 50&#xa0;years had osteopenia, while osteoporosis was observed in 10.7%, with higher prevalence in women (18.6% vs. 2.6%) and increasing with age. Using MRPO criteria, osteoporosis prevalence rose to 14.8%.</p> Conclusion <p>The BMD of the OsteoSER study population is similar to that of MRPO and NHANES III. Physical activity positively influences peak bone mass, while smoking has detrimental effects.</p>

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An update in bone mineral density status in Spain: the OsteoSER study

  • 期刊论文

  • 发表日期：

    2025年3月7日

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  • Carmen Gómez-Vaquero,
  • Marta Domínguez-Álvaro,
  • Daniel Seoane-Mato,
  • Pilar Peris Bernal,
  • Santos Castañeda,
  • Eduardo Kanterewicz Binstock,
  • Ramón Mazzucchelli Esteban,
  • Luis Arboleya Rodríguez,
  • Miguel Bernard,
  • Antonio Álvarez-Cienfuegos,
  • Blanca Correa,
  • Luis María Jiménez Liñán,
  • Carmen Mateo Pascual,
  • Ma Mercedes Molina del Rio,
  • Mercedes Retamal Ortiz,
  • Aida Fátima López Laguna,
  • Ruth Molera Valero,
  • Sara Alvar Pariente,
  • Antonio Pascual-Vergara,
  • Adolfo Arias Senso,
  • Nuria Pérez Gutiérrez,
  • Soledad García Frías,
  • David Bouza Alvárez,
  • Susana Sostrés,
  • Daniel Suárez Hernandez,
  • Ana Zamora Casal,
  • Cristina García Ramírez,
  • Enrique González-Dávila,
  • Carmen Valdés y Llorca,
  • Estrella Robles Fernández,
  • Alejandra Montero Costa,
  • Lourdes Pulido Izquierdo,
  • Miguel Ángel Álvaro Sánchez,
  • Mª Pilar Pérez Morandeira,
  • Cristina Momblan Trejo,
  • Manuel Jiménez Rodríguez,
  • Ana Elena Collada Fernández,
  • Manuel Carmona González,
  • Sara Gracia Baena,
  • M Ángeles Escribano Berdún,
  • María Anadón González,
  • Raquel Cantoral González,
  • Paloma Rodríguez Turégano,
  • Ma Pilar Moreno Cano,
  • Celia Ramos Díaz,
  • Nuria María Esquinas,
  • José Luis Antón Castelló,
  • Sara Barcat Zarate,
  • Daniela Ruiz García,
  • Inés Ruiz Sevilla,
  • Itziar María Bernabeu González de la Higuera,
  • Ainoa Selma García,
  • Cristina Ruiz Pavón,
  • Pedro Jesús Lacalle Chanivet,
  • Avelina Menacho Labrador,
  • Mª José Chacón Campanario,
  • Rocío Ruiz Pérez,
  • Ana Ma Gallegos Álvarez,
  • Cinthia Guadalupe de León,
  • Nazaret Martínez Mancebo,
  • Rocio Chica Hoyo,
  • Balbina Marin d Prada,
  • Mª Dolors Peleato Catalan,
  • Bàrbara Navarro Aranbudo,
  • Nuria Flores Gudiño,
  • Jessuca Bureda Sancho,
  • Sonia Perez Garcia,
  • Angelo Paolo Rosario Vargas,
  • Mª Teresa García Curiel,
  • Carlota Álvarez Carvajal,
  • Maria Gallardo Gallardo,
  • Jesús Caeiro Castelao,
  • Miriam Dorado Gómez,
  • Carmen Alicia López Álvarez,
  • Eloísa de Alcalá Torreiro,
  • Francisco Javier Maestro Saavedra,
  • Ana Losada Ábalo,
  • Francisco Javier Rodríguez García,
  • Ana Palomares López,
  • Mª Roser Urpinas Vila,
  • Begoña González Carrión,
  • Marta Poch i Mora,
  • Cristina Sin Benítez,
  • Anna Ramón Velasco,
  • Roxana Zevallos,
  • Ana Santos Varela,
  • José Luis Gea González,
  • Carlota Quiroga Fernández,
  • Alba Díaz Aquino,
  • Diego García de la Fuente,
  • Eduardo Acevedo Martel

摘要

Summary

Bone mineral density (BMD) reference data for the Spanish population come from the Multicenter Research Project on Osteoporosis (MRPO) in 1989. The OsteoSER study updated Spanish BMD reference data, showing similarities with MRPO and NHANES III. Peak bone mass occurred at 20–39 years, positively associated with physical activity and negatively with smoking. Osteopenia affected 54.4%, and osteoporosis 10.7% of adults ≥ 50 years, with higher prevalence in women and increasing with age.

Purpose

This study aimed to estimate the distribution of BMD in lumbar spine, femoral neck, and total hip in the Spanish population aged ≥ 20 years and compare it with MRPO and NHANES III data.

Methods

A multicenter cross-sectional observational study was conducted in a White Spanish population aged 20–80 years across 12 urban and rural municipalities. Participants were selected by primary care physicians based on inclusion criteria (stratified by sex, age, and BMI) and exclusion criteria (artifacts in BMD imaging in participants of all ages and conditions affecting bone density in younger participants). A vehicle with a Hologic® Horizon W densitometer traveled to each municipality.

Results

A total of 1522 participants underwent densitometry (51.8% men). Peak bone mass is reached at ages 20–39 years in both sexes at all sites. BMD was positively associated with height, BMI, and physical activity and negatively with smoking (p < 0.05). The distribution of BMD by age and sex was comparable to MRPO and NHANES III. We found that 54.4% of postmenopausal women and men ≥ 50 years had osteopenia, while osteoporosis was observed in 10.7%, with higher prevalence in women (18.6% vs. 2.6%) and increasing with age. Using MRPO criteria, osteoporosis prevalence rose to 14.8%.

Conclusion

The BMD of the OsteoSER study population is similar to that of MRPO and NHANES III. Physical activity positively influences peak bone mass, while smoking has detrimental effects.