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<p>Brain tumors are the most common solid malignancies in childhood. Improved survival through structured multimodal treatment strategies has shifted the focus toward minimizing long-term treatment-related morbidity. Modern pediatric neuro-oncology relies on molecular stratification, interdisciplinary decision-making, and centralized reference diagnostics. Radiotherapy remains a&#xa0;key component of treatment. High-precision target volume definition, conformal techniques, and normal tissue complication probability (NTCP)-based risk modeling enable a&#xa0;careful balance between tumor control and normal tissue preservation. Proton therapy has become standard in many pediatric indications, significantly reducing the integral dose as well as the risk of endocrine, neurocognitive, and secondary malignancy sequelae. Helium ions represent a&#xa0;logical technological advancement, offering further potential for precision and dose reduction.</p>

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Strahlentherapie kindlicher Hirntumoren

  • 期刊论文

  • 发表日期：

    2026年5月13日

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  • S. Harrabi

摘要

Brain tumors are the most common solid malignancies in childhood. Improved survival through structured multimodal treatment strategies has shifted the focus toward minimizing long-term treatment-related morbidity. Modern pediatric neuro-oncology relies on molecular stratification, interdisciplinary decision-making, and centralized reference diagnostics. Radiotherapy remains a key component of treatment. High-precision target volume definition, conformal techniques, and normal tissue complication probability (NTCP)-based risk modeling enable a careful balance between tumor control and normal tissue preservation. Proton therapy has become standard in many pediatric indications, significantly reducing the integral dose as well as the risk of endocrine, neurocognitive, and secondary malignancy sequelae. Helium ions represent a logical technological advancement, offering further potential for precision and dose reduction.