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<p>Frailty is a&#xa0;common geriatric syndrome in older patients with cancer. It affects prognosis and treatment tolerance in various ways. Frailty and cancer share several common risk factors, which are reflected in the hallmarks of aging. An oncogeriatric assessment with management (GAME) provides the opportunity to detect frailty and its related geriatric impairments and offers the possibility to compensate for frailty-associated vulnerability. Thus, higher-grade treatment-associated toxicities of the provided oncological treatments are reduced. Furthermore, treatment completion rates and quality of life can be improved by GAME. The following review article provides an overview of the general definition of physical and social frailty, its significance in oncology, and the evidence for GAME. Lastly, first study results of frailty-adapted treatment approaches are summarized.</p>

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Frailty in der Onkogeriatrie

  • 期刊论文

  • 发表日期：

    2026年4月16日

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  • Nina Rosa Neuendorff,
  • Rainer Wirth,
  • Barbara Deschler-Baier

摘要

Frailty is a common geriatric syndrome in older patients with cancer. It affects prognosis and treatment tolerance in various ways. Frailty and cancer share several common risk factors, which are reflected in the hallmarks of aging. An oncogeriatric assessment with management (GAME) provides the opportunity to detect frailty and its related geriatric impairments and offers the possibility to compensate for frailty-associated vulnerability. Thus, higher-grade treatment-associated toxicities of the provided oncological treatments are reduced. Furthermore, treatment completion rates and quality of life can be improved by GAME. The following review article provides an overview of the general definition of physical and social frailty, its significance in oncology, and the evidence for GAME. Lastly, first study results of frailty-adapted treatment approaches are summarized.