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Background <p>Radiotherapy is an essential part of cancer therapy in general and particularly of the treatment of bone metastases.</p> Objective <p>This article aims to give an overview of the indications, technique, regimes, outcomes, and limitations of radiotherapy for the treatment of bone metastases.</p> Materials and methods <p>The current literature and guidelines on radiation therapy of bone metastases were reviewed under the guidance of experts from the Department of Radiotherapy and Orthopedics at the University Hospital of Freiburg (Comprehensive Cancer Center Freiburg, CCCF).</p> Results <p>Radiation therapy successfully reduces pain in 60% of patients with bone metastases within 2–3&#xa0;weeks. It induces reossification within 3–6&#xa0;months. In a&#xa0;palliative setting, fractionation can be reduced to even single-fraction treatments, resulting in nearly the same pain reduction in symptomatic bone metastases as compared to multiple-fraction treatment regimes. Stereotactic ablative radiotherapy seems to have the greatest potential in the treatment of oligometastatic disease.</p> Conclusion <p>Radiation therapy is a&#xa0;potent tool to treat most bone metastases—not only in palliative but also in curative settings. More recently developed techniques of radiotherapy have even increased the therapeutic effectiveness while reducing side effects in surrounding organs at risk.</p>

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Strahlentherapie ossärer Metastasen

  • 期刊论文

  • 发表日期：

    2025年1月23日

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  • Lukas Klein,
  • Georg Herget,
  • Hagen Schmal,
  • Anca-Ligia Grosu,
  • Tanja Sprave,
  • Raluca Stoian

摘要

Background

Radiotherapy is an essential part of cancer therapy in general and particularly of the treatment of bone metastases.

Objective

This article aims to give an overview of the indications, technique, regimes, outcomes, and limitations of radiotherapy for the treatment of bone metastases.

Materials and methods

The current literature and guidelines on radiation therapy of bone metastases were reviewed under the guidance of experts from the Department of Radiotherapy and Orthopedics at the University Hospital of Freiburg (Comprehensive Cancer Center Freiburg, CCCF).

Results

Radiation therapy successfully reduces pain in 60% of patients with bone metastases within 2–3 weeks. It induces reossification within 3–6 months. In a palliative setting, fractionation can be reduced to even single-fraction treatments, resulting in nearly the same pain reduction in symptomatic bone metastases as compared to multiple-fraction treatment regimes. Stereotactic ablative radiotherapy seems to have the greatest potential in the treatment of oligometastatic disease.

Conclusion

Radiation therapy is a potent tool to treat most bone metastases—not only in palliative but also in curative settings. More recently developed techniques of radiotherapy have even increased the therapeutic effectiveness while reducing side effects in surrounding organs at risk.