<p>The effect of different fuel mixtures (C₂H₂, C₃H₆, C₃H₈, C₂H₂+C₃H₆, C₂H₂+C₃H₈) on the acceleration of the gas detonation flame under the same detonation tube gun structure has been studied using numerical simulation. The trends of the internal parameters of the gun, as well as the variations of the gas flow velocity, temperature and pressure at the gun outlet with time were analyzed. At equivalence ratio of 1, the simulation results demonstrate that acetylene fuel produces the shortest detonation time and reaches the highest average gas flow velocity of 1031.6 m/s at the gun exit, and the acetylene detonation reaches the highest average temperature of 2750.6 K. The fastest speeds of OH and other parameters were produced by the detonation of C₂H₂ and its mixture fuels, which represents the fastest flame propagation. Propane detonation at the outlet of the gun to reach the maximum pressure of 0.66 MPa; internal to the gun, detonation of CO₂ produced by the majority of the distribution of the wall region. Different fuel compositions lead to variations in the detonation spray effects, and altering the fuel composition can meet diverse requirements for detonation and spray particle characteristics.</p>