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<p>Statins constitute a common class of therapeutic agents indicated for the treatment of hyperlipidaemia, cerebrovascular, and cardiovascular disease. Statins are widely used due to their well-established cardiovascular benefits, pleiotropic effects (e.g. atherosclerotic plaque-stabilising effects), and favourable safety profile. Yet, with its widespread usage, clinicians should be aware of its common side effect in the form of statin-associated muscular symptoms that potentially develop in 5–10% of patients. While most of these adverse effects are benign and amenable to dose reduction or switching to an alternative statin, rare cases occur where patients develop severe myopathies, rhabdomyolysis, and even a potentially dangerous form of autoimmune necrotising myositis. In this narrative review article, we sought to provide a practical and up-to-date overview and approach to statin-associated myotoxicity for general internists who would manage these patients in their practice.</p>

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Statin-Related Myotoxicity: A Narrative Review and Practical Approach for General Internists

  • 期刊论文

  • 发表日期：

    2026年6月24日

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  • Isaac KS Ng,
  • Kevin SH Teo,
  • Hui Yang,
  • Wilson GW Goh,
  • Christopher Thong,
  • Li Feng Tan,
  • Desmond B. Teo,
  • Anselm Mak

摘要

Statins constitute a common class of therapeutic agents indicated for the treatment of hyperlipidaemia, cerebrovascular, and cardiovascular disease. Statins are widely used due to their well-established cardiovascular benefits, pleiotropic effects (e.g. atherosclerotic plaque-stabilising effects), and favourable safety profile. Yet, with its widespread usage, clinicians should be aware of its common side effect in the form of statin-associated muscular symptoms that potentially develop in 5–10% of patients. While most of these adverse effects are benign and amenable to dose reduction or switching to an alternative statin, rare cases occur where patients develop severe myopathies, rhabdomyolysis, and even a potentially dangerous form of autoimmune necrotising myositis. In this narrative review article, we sought to provide a practical and up-to-date overview and approach to statin-associated myotoxicity for general internists who would manage these patients in their practice.