Scholarlink

Background <p>Major osteoporotic fracture (MOF) is associated with increased mortality; however, few studies in postmenopausal women have examined racial and ethnic differences in 1-year and 5-year mortality following MOF.</p> Objective <p>To assess 1-year and 5-year mortality following MOF by race and ethnicity.</p> Design <p>This prospective cohort study included postmenopausal women enrolled in the Women’s Health Initiative (WHI), a population-based, multisite US study. Participants were followed from September 1994 to February 2023. Data were analyzed between August 2023 and November 2023.</p> Participants <p>Postmenopausal women aged 50 to 79&#xa0;years old who experienced a MOF (<i>N</i> = 32,675 in 1&#xa0;year and 29,506 in 5&#xa0;years following MOF).</p> Main Measures <p>Self-reported race and ethnicity. All-cause mortality was determined by death certificates, reports of surrogates, and the National Death Index Search.</p> Key Results <p>The baseline mean age of participants was 77.0 [SD = 8.5] years with 31,223 [95.6%] White participants in the 1-year mortality analysis, and 76.3 [SD = 8.5] years with 28,212 [95.6%] White participants in the 5-year mortality analysis. In fully adjusted models, compared to White women, Black women had a higher risk of mortality (adjusted odds ratio (aOR) = 1.42, 95% CI [1.06, 1.90], while Asian women had a lower risk of mortality (aOR = 0.48 95% CI [0.27, 0.88]), within 1&#xa0;year following MOF. Compared to White women, the mortality risk within 5&#xa0;years after MOF was significantly higher among American Indian/Alaska Native (aOR = 3.30, 95% CI [1.65, 6.60]) and lower among Asian (aOR = 0.58, 95% CI [0.42,0.80]) women. While there were no mortality differences by ethnicity 1&#xa0;year following MOF, Hispanic/Latina women were less likely to die 5&#xa0;years following MOF (aOR = 0.74, [95% CI 0.57–0.96]) compared to Non-Hispanic/Latina women.</p> Conclusions <p>In this large prospective study, mortality following MOF differed by race. Future research is needed to delineate the mechanism behind these associations.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Race, Ethnicity, and Mortality Following Major Osteoporotic Fracture: Results from the Women’s Health Initiative Study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月24日

查看全文
  • Michaela Juels,
  • Joseph C. Larson,
  • Kristine E. Ensrud,
  • Marcia L. Stefanick,
  • Aladdin H. Shadyab,
  • Lorena Garcia,
  • Rami Nassir,
  • Peter F. Schnatz,
  • Rebecca Nelson,
  • Carolyn J. Crandall

摘要

Background

Major osteoporotic fracture (MOF) is associated with increased mortality; however, few studies in postmenopausal women have examined racial and ethnic differences in 1-year and 5-year mortality following MOF.

Objective

To assess 1-year and 5-year mortality following MOF by race and ethnicity.

Design

This prospective cohort study included postmenopausal women enrolled in the Women’s Health Initiative (WHI), a population-based, multisite US study. Participants were followed from September 1994 to February 2023. Data were analyzed between August 2023 and November 2023.

Participants

Postmenopausal women aged 50 to 79 years old who experienced a MOF (N = 32,675 in 1 year and 29,506 in 5 years following MOF).

Main Measures

Self-reported race and ethnicity. All-cause mortality was determined by death certificates, reports of surrogates, and the National Death Index Search.

Key Results

The baseline mean age of participants was 77.0 [SD = 8.5] years with 31,223 [95.6%] White participants in the 1-year mortality analysis, and 76.3 [SD = 8.5] years with 28,212 [95.6%] White participants in the 5-year mortality analysis. In fully adjusted models, compared to White women, Black women had a higher risk of mortality (adjusted odds ratio (aOR) = 1.42, 95% CI [1.06, 1.90], while Asian women had a lower risk of mortality (aOR = 0.48 95% CI [0.27, 0.88]), within 1 year following MOF. Compared to White women, the mortality risk within 5 years after MOF was significantly higher among American Indian/Alaska Native (aOR = 3.30, 95% CI [1.65, 6.60]) and lower among Asian (aOR = 0.58, 95% CI [0.42,0.80]) women. While there were no mortality differences by ethnicity 1 year following MOF, Hispanic/Latina women were less likely to die 5 years following MOF (aOR = 0.74, [95% CI 0.57–0.96]) compared to Non-Hispanic/Latina women.

Conclusions

In this large prospective study, mortality following MOF differed by race. Future research is needed to delineate the mechanism behind these associations.