Scholarlink

Purpose <p>To characterize the computed tomography (CT) features of severe fever with thrombocytopenia syndrome (SFTS) and to identify imaging features predictive of an adverse prognosis.</p> Materials and methods <p>Thirty-one patients diagnosed with SFTS between July 2017 and August 2025 and who underwent whole-body CT (17 men, 14 women; mean age, 75.3&#xa0;years; 24 survivors, 7 non-survivors) were retrospectively reviewed. CT findings of the chest, abdominal organs, and regional lymph nodes were assessed. Initial CT scans (n = 31) were obtained a mean of 3.8&#xa0;days (range, 0–7) after symptom onset, and follow-up CT scans (n = 20) were performed in 17 patients a mean of 6.0&#xa0;days (range 1–18) after the initial scan, giving a total of 51 examinations. Additionally, for three cases in which autopsy was performed, correlation analysis was performed between the CT findings and pathological findings.</p> Results <p>On initial CT, the most frequent finding was regional lymphadenopathy (n = 30, 96.8%), most commonly involving inguinal (n = 17, 54.8%) and axillary nodes (n = 11, 35.5%). Perinodal fat stranding was observed in 29 patients (93.5%). The most common thoracic finding was ground-glass opacity (GGO) (n = 17, 54.8%), followed by bronchial wall thickening (n = 16, 51.6%) and interlobular septal thickening (n = 15, 48.4%). Among abdominal organs, splenomegaly was the most frequent finding (n = 25, 80.6%), followed by renal enlargement (n = 15, 48.4%). On follow-up CT, the most frequently observed changes compared with the initial CT were increased renal volume (n = 17, 85%) and increased hepatic volume (n = 14, 70%). GGO was significantly more frequent in non-survivors than in survivors.</p> Conclusions <p>Characteristic CT findings of SFTS include regional lymphadenopathy with perinodal fat stranding, followed by splenomegaly and GGO. GGO may be an imaging finding predictive of an adverse prognosis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Whole-body CT characteristics of patients with severe fever with thrombocytopenia syndrome

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月1日

查看全文
  • Haruka Sato,
  • Fumito Okada,
  • Ryuichi Takenaka,
  • Ryuzo Abe,
  • Haruto Nishida,
  • Yoshiki Asayama

摘要

Purpose

To characterize the computed tomography (CT) features of severe fever with thrombocytopenia syndrome (SFTS) and to identify imaging features predictive of an adverse prognosis.

Materials and methods

Thirty-one patients diagnosed with SFTS between July 2017 and August 2025 and who underwent whole-body CT (17 men, 14 women; mean age, 75.3 years; 24 survivors, 7 non-survivors) were retrospectively reviewed. CT findings of the chest, abdominal organs, and regional lymph nodes were assessed. Initial CT scans (n = 31) were obtained a mean of 3.8 days (range, 0–7) after symptom onset, and follow-up CT scans (n = 20) were performed in 17 patients a mean of 6.0 days (range 1–18) after the initial scan, giving a total of 51 examinations. Additionally, for three cases in which autopsy was performed, correlation analysis was performed between the CT findings and pathological findings.

Results

On initial CT, the most frequent finding was regional lymphadenopathy (n = 30, 96.8%), most commonly involving inguinal (n = 17, 54.8%) and axillary nodes (n = 11, 35.5%). Perinodal fat stranding was observed in 29 patients (93.5%). The most common thoracic finding was ground-glass opacity (GGO) (n = 17, 54.8%), followed by bronchial wall thickening (n = 16, 51.6%) and interlobular septal thickening (n = 15, 48.4%). Among abdominal organs, splenomegaly was the most frequent finding (n = 25, 80.6%), followed by renal enlargement (n = 15, 48.4%). On follow-up CT, the most frequently observed changes compared with the initial CT were increased renal volume (n = 17, 85%) and increased hepatic volume (n = 14, 70%). GGO was significantly more frequent in non-survivors than in survivors.

Conclusions

Characteristic CT findings of SFTS include regional lymphadenopathy with perinodal fat stranding, followed by splenomegaly and GGO. GGO may be an imaging finding predictive of an adverse prognosis.