Scholarlink

Objectives <p>To evaluate the distribution patterns of sarcoidosis involvement on FDG-PET/CT in patients with known or suspected cardiac sarcoidosis (CS), with a particular focus on upper abdominal lymph nodes (LN) (periportal LN [PLN], anterior pancreaticoduodenal LN [APDLN], and posterior pancreaticoduodenal LN [PPDLN]) and the association of them with other lesions and myocardium.</p> Methods <p>We identified 861 FDG-PET/CT scans performed between July 2016 and August 2024 in patients with known or suspected CS, and included 178 cases for analysis of FDG uptake patterns suggestive of sarcoid involvement. FDG-positive LNs or regions were classified as sarcoidosis-related based on treatment response, characteristic uptake patterns, or histological confirmation. The occurrence ratio of FDG-positive lymph nodes or regions was also assessed in relation to myocardial FDG uptake patterns.</p> Results <p>FDG uptake was observed most frequently in hilar and mediastinal LNs (79% and 76%, respectively). Upper abdominal LN uptake was observed in 49.4% of patients, most commonly in the PLN (31.5%), APDLN (38.2%), and PPDLN (37.1%). Heatmap analyses revealed strong co-occurrence between thoracic and upper abdominal LNs, suggesting a lymphatic dissemination pattern. Peripheral LNs such as axillary, subclavian, and inguinal/pelvic stations demonstrated low uptake and minimal co-occurrence.</p> Conclusions <p>FDG-PET/CT provides valuable insight into the structured lymphatic dissemination of sarcoidosis. Frequent FDG uptake in upper abdominal lymph nodes, particularly when accompanied by thoracic involvement, represents a characteristic finding in sarcoidosis. Recognition of this pattern can improve diagnostic accuracy and help differentiate sarcoidosis from other systemic diseases.</p> Secondary abstract <p>This study assessed lymph node involvement on FDG-PET/CT in patients with suspected or known cardiac sarcoidosis, revealing distinct dissemination patterns into the upper abdomen. These findings enhance understanding of disease pathophysiology and may improve diagnostic evaluation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

FDG uptake in upper abdominal lymph node as a distinctive pattern in sarcoidosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月5日

查看全文
  • Ryogo Minamimoto,
  • Yumi Abe,
  • Ryota Morimoto,
  • Rintato Ito,
  • Naotoshi Fujita,
  • Toyoaki Murohara,
  • Katsuhiko Kato,
  • Shinji Naganawa

摘要

Objectives

To evaluate the distribution patterns of sarcoidosis involvement on FDG-PET/CT in patients with known or suspected cardiac sarcoidosis (CS), with a particular focus on upper abdominal lymph nodes (LN) (periportal LN [PLN], anterior pancreaticoduodenal LN [APDLN], and posterior pancreaticoduodenal LN [PPDLN]) and the association of them with other lesions and myocardium.

Methods

We identified 861 FDG-PET/CT scans performed between July 2016 and August 2024 in patients with known or suspected CS, and included 178 cases for analysis of FDG uptake patterns suggestive of sarcoid involvement. FDG-positive LNs or regions were classified as sarcoidosis-related based on treatment response, characteristic uptake patterns, or histological confirmation. The occurrence ratio of FDG-positive lymph nodes or regions was also assessed in relation to myocardial FDG uptake patterns.

Results

FDG uptake was observed most frequently in hilar and mediastinal LNs (79% and 76%, respectively). Upper abdominal LN uptake was observed in 49.4% of patients, most commonly in the PLN (31.5%), APDLN (38.2%), and PPDLN (37.1%). Heatmap analyses revealed strong co-occurrence between thoracic and upper abdominal LNs, suggesting a lymphatic dissemination pattern. Peripheral LNs such as axillary, subclavian, and inguinal/pelvic stations demonstrated low uptake and minimal co-occurrence.

Conclusions

FDG-PET/CT provides valuable insight into the structured lymphatic dissemination of sarcoidosis. Frequent FDG uptake in upper abdominal lymph nodes, particularly when accompanied by thoracic involvement, represents a characteristic finding in sarcoidosis. Recognition of this pattern can improve diagnostic accuracy and help differentiate sarcoidosis from other systemic diseases.

Secondary abstract

This study assessed lymph node involvement on FDG-PET/CT in patients with suspected or known cardiac sarcoidosis, revealing distinct dissemination patterns into the upper abdomen. These findings enhance understanding of disease pathophysiology and may improve diagnostic evaluation.