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Background <p>Stroke, frequently associated with carotid artery disease, is evaluated using carotid computed tomography angiography (CTA). Dual-energy CTA (DE-CTA) enhances imaging quality but presents challenges in maintaining high image clarity with low-dose scans.</p> Objectives <p>To compare the image quality of 50&#xa0;keV virtual monoenergetic images (VMI) generated using Deep Learning Image Reconstruction (DLIR) and Adaptive Statistical Iterative Reconstruction-V (ASIR-V) algorithms under a triple-low scanning protocol in carotid CTA.</p> Methods <p>A prospective study was conducted with 120 patients undergoing DE-CTA. The control group (Group 1), with a noise index (NI) of 4.0 and a contrast agent dose of 0.5&#xa0;mL/kg, used the ASIR-V algorithm. The experimental group was divided into four subgroups: Group 2 (ASIR-V 50%), Group 3 (DLIR-L), Group 4 (DLIR-M), and Group 5 (DLIR-H), with a higher NI of 13.0 and a reduced contrast agent dose of 0.4&#xa0;mL/kg. Objective image quality was assessed through signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and standard deviation (SD), while subjective quality was evaluated using a 5-point Likert scale. Radiation dose and contrast agent volume were also measured.</p> Results <p>The triple-low scanning protocol reduced radiation exposure by 53.2%, contrast agent volume by 19.7%, and injection rate by 19.8%. The DLIR-H setting outperformed ASIR-V, demonstrating superior image quality, better noise suppression, and improved contrast in small vessels. VMI at 50&#xa0;keV showed enhanced diagnostic clarity with minimal radiation and contrast agent usage.</p> Conclusion <p>The DLIR algorithm, particularly at high settings, significantly enhances image quality in DE-CTA VMI under a triple-low scanning protocol, offering a better balance between radiation dose reduction and image clarity.</p>

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Comparison of DLIR and ASIR-V algorithms for virtual monoenergetic imaging in carotid CTA under a triple-low protocol

  • 期刊论文

  • 发表日期：

    2025年9月9日

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  • Juan Long,
  • Chenzi Wang,
  • Meng Yu,
  • Xiaohan Liu,
  • Wenbei Xu,
  • Zhongxiao Liu,
  • Chong Wang,
  • Yang Wu,
  • Aiyun Sun,
  • Shuai Zhang,
  • Chunfeng Hu,
  • Kai Xu,
  • Yankai Meng

摘要

Background

Stroke, frequently associated with carotid artery disease, is evaluated using carotid computed tomography angiography (CTA). Dual-energy CTA (DE-CTA) enhances imaging quality but presents challenges in maintaining high image clarity with low-dose scans.

Objectives

To compare the image quality of 50 keV virtual monoenergetic images (VMI) generated using Deep Learning Image Reconstruction (DLIR) and Adaptive Statistical Iterative Reconstruction-V (ASIR-V) algorithms under a triple-low scanning protocol in carotid CTA.

Methods

A prospective study was conducted with 120 patients undergoing DE-CTA. The control group (Group 1), with a noise index (NI) of 4.0 and a contrast agent dose of 0.5 mL/kg, used the ASIR-V algorithm. The experimental group was divided into four subgroups: Group 2 (ASIR-V 50%), Group 3 (DLIR-L), Group 4 (DLIR-M), and Group 5 (DLIR-H), with a higher NI of 13.0 and a reduced contrast agent dose of 0.4 mL/kg. Objective image quality was assessed through signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and standard deviation (SD), while subjective quality was evaluated using a 5-point Likert scale. Radiation dose and contrast agent volume were also measured.

Results

The triple-low scanning protocol reduced radiation exposure by 53.2%, contrast agent volume by 19.7%, and injection rate by 19.8%. The DLIR-H setting outperformed ASIR-V, demonstrating superior image quality, better noise suppression, and improved contrast in small vessels. VMI at 50 keV showed enhanced diagnostic clarity with minimal radiation and contrast agent usage.

Conclusion

The DLIR algorithm, particularly at high settings, significantly enhances image quality in DE-CTA VMI under a triple-low scanning protocol, offering a better balance between radiation dose reduction and image clarity.